2. Antibody-drug Conjugate/ADC Related
  3. Radionuclide-Drug Conjugates (RDCs)
  4. NH2 DOTA-GA

NH2 DOTA-GA is a DOTA-based metal chelator that can be used to prepare radionuclide drug conjugates (RDCs) whose carboxylic acid groups can complex metal ions. For example, NH2 DOTA-GA complexes Gd(III) ions.

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NH2 DOTA-GA Chemical Structure

NH2 DOTA-GA Chemical Structure

CAS No. : 1639843-65-4

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NH2 DOTA-GA Related Antibodies

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Description

NH2 DOTA-GA is a DOTA-based metal chelator that can be used to prepare radionuclide drug conjugates (RDCs) whose carboxylic acid groups can complex metal ions. For example, NH2 DOTA-GA complexes Gd(III) ions.

IC50 & Target

RDC Bifunctional Chelator

 

Molecular Weight

518.56

Formula

C21H38N6O9
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCN)CCC(N1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1)C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (241.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9284 mL 9.6421 mL 19.2842 mL
5 mM 0.3857 mL 1.9284 mL 3.8568 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9284 mL 9.6421 mL 19.2842 mL 48.2104 mL
5 mM 0.3857 mL 1.9284 mL 3.8568 mL 9.6421 mL
10 mM 0.1928 mL 0.9642 mL 1.9284 mL 4.8210 mL
15 mM 0.1286 mL 0.6428 mL 1.2856 mL 3.2140 mL
20 mM 0.0964 mL 0.4821 mL 0.9642 mL 2.4105 mL
25 mM 0.0771 mL 0.3857 mL 0.7714 mL 1.9284 mL
30 mM 0.0643 mL 0.3214 mL 0.6428 mL 1.6070 mL
40 mM 0.0482 mL 0.2411 mL 0.4821 mL 1.2053 mL
50 mM 0.0386 mL 0.1928 mL 0.3857 mL 0.9642 mL
60 mM 0.0321 mL 0.1607 mL 0.3214 mL 0.8035 mL
80 mM 0.0241 mL 0.1205 mL 0.2411 mL 0.6026 mL
100 mM 0.0193 mL 0.0964 mL 0.1928 mL 0.4821 mL
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NH2 DOTA-GA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NH2 DOTA-GA1639843-65-4Radionuclide-Drug Conjugates (RDCs)Inhibitorinhibitorinhibit

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