NH2-PEG3-VC-PAB-MMAE

Name: NH2-PEG3-VC-PAB-MMAE
Brand: MedChemExpress
SKU: HY-164239
Rating: 4.5 (1 reviews)

Cat. No.: HY-164239 Purity: 99.10%: FAQs
Data Sheet SDS COA Handling Instructions

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NH2-PEG3-VC-PAB-MMAE is a drug-linker conjugate for ADC, consisting of a cleavable ADC linker (NH2-PEG3-VC-PAB) and a potent tubulin inhibitor Monomethyl auristatin E (MMAE) (HY-15162). NH2-PEG3-VC-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

NH2-PEG3-VC-PAB-MMAE Chemical Structure

CAS No. : 2641442-97-7

Size	Price	Stock	Quantity
5 mg	USD 380	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Small Molecules:

•Related Proteins:

View All Drug-Linker Conjugates for ADC Isoform Specific Products:

View All Isoforms

Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1312.64

Formula

C₆₆H₁₀₉N₁₁O₁₆

CAS No.

2641442-97-7

Appearance

Solid

Color

White to off-white

SMILES

O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(COCCOCCOCCN)=O)=O)=O)=O)=O)=O)=O)OC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 90 mg/mL (68.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7618 mL	3.8091 mL	7.6182 mL
5 mM	0.1524 mL	0.7618 mL	1.5236 mL
10 mM	0.0762 mL	0.3809 mL	0.7618 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.10%

Select Batch:

Data Sheet (269 KB) SDS (252 KB)

COA (248 KB) HNMR (239 KB) RP-HPLC (246 KB) MS (68 KB)

Handling Instructions (2659 KB)

References

[1]. Xiwu Hui, et al. An Innovative Site-Specific Anti-HER2 Antibody-Drug Conjugate with High Homogeneity and Improved Therapeutic Index. Onco Targets Ther. 2022 Apr 8:15:331-343. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.7618 mL	3.8091 mL	7.6182 mL	19.0456 mL
	5 mM	0.1524 mL	0.7618 mL	1.5236 mL	3.8091 mL
	10 mM	0.0762 mL	0.3809 mL	0.7618 mL	1.9046 mL
	15 mM	0.0508 mL	0.2539 mL	0.5079 mL	1.2697 mL
	20 mM	0.0381 mL	0.1905 mL	0.3809 mL	0.9523 mL
	25 mM	0.0305 mL	0.1524 mL	0.3047 mL	0.7618 mL
	30 mM	0.0254 mL	0.1270 mL	0.2539 mL	0.6349 mL
	40 mM	0.0190 mL	0.0952 mL	0.1905 mL	0.4761 mL
	50 mM	0.0152 mL	0.0762 mL	0.1524 mL	0.3809 mL
	60 mM	0.0127 mL	0.0635 mL	0.1270 mL	0.3174 mL