2. Antibody-drug Conjugate/ADC Related Cytoskeleton Cell Cycle/DNA Damage
  3. Drug-Linker Conjugates for ADC Microtubule/Tubulin
  4. NH2-PEG3-VC-PAB-MMAE

NH2-PEG3-VC-PAB-MMAE is a drug-linker conjugate for ADC, consisting of a cleavable ADC linker (NH2-PEG3-VC-PAB) and a potent tubulin inhibitor Monomethyl auristatin E (MMAE) (HY-15162). NH2-PEG3-VC-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

NH2-PEG3-VC-PAB-MMAE Chemical Structure

NH2-PEG3-VC-PAB-MMAE Chemical Structure

CAS No. : 2641442-97-7

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5 mg USD 380 Get quote 4 - 6 weeks 4 - 6 weeks 3 - 5 weeks
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Based on 1 publication(s) in Google Scholar

NH2-PEG3-VC-PAB-MMAE Related Antibodies

Top Publications Citing Use of Products

View All Drug-Linker Conjugates for ADC Isoform Specific Products:

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Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

NH2-PEG3-VC-PAB-MMAE is a drug-linker conjugate for ADC, consisting of a cleavable ADC linker (NH2-PEG3-VC-PAB) and a potent tubulin inhibitor Monomethyl auristatin E (MMAE) (HY-15162). NH2-PEG3-VC-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs)[1].

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NH2-PEG3-VC-PAB-MMAE Related Antibodies
Molecular Weight

1312.64

Formula

C66H109N11O16
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(COCCOCCOCCN)=O)=O)=O)=O)=O)=O)=O)OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 90 mg/mL (68.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7618 mL 3.8091 mL 7.6182 mL
5 mM 0.1524 mL 0.7618 mL 1.5236 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7618 mL 3.8091 mL 7.6182 mL 19.0456 mL
5 mM 0.1524 mL 0.7618 mL 1.5236 mL 3.8091 mL
10 mM 0.0762 mL 0.3809 mL 0.7618 mL 1.9046 mL
15 mM 0.0508 mL 0.2539 mL 0.5079 mL 1.2697 mL
20 mM 0.0381 mL 0.1905 mL 0.3809 mL 0.9523 mL
25 mM 0.0305 mL 0.1524 mL 0.3047 mL 0.7618 mL
30 mM 0.0254 mL 0.1270 mL 0.2539 mL 0.6349 mL
40 mM 0.0190 mL 0.0952 mL 0.1905 mL 0.4761 mL
50 mM 0.0152 mL 0.0762 mL 0.1524 mL 0.3809 mL
60 mM 0.0127 mL 0.0635 mL 0.1270 mL 0.3174 mL
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NH2-PEG3-VC-PAB-MMAE Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NH2-PEG3-VC-PAB-MMAE2641442-97-7Drug-Linker Conjugates for ADCMicrotubule/Tubulindrug-linker conjugate for ADCMMAEcleavable ADC linkerInhibitorinhibitorinhibit

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