Nirvanol (Synonyms: Ethylphenylhydantoin; Phenylethyihydantoin; Desmethylmephenytoin)

Cat. No.: HY-W012481 Purity: ≥95.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Nirvanol is a metabolite of Mephenytoin (HY-B1184) that exerts anticonvulsant effects in the Maximal Electroshock (M.E.S.) seizure model in mice. The ED₅₀ of Nirvanol is 23 mg/kg (measured 30 minutes after intraperitoneal injection) and 30 mg/kg (measured 2 hours after intraperitoneal injection). Nirvanol shows potential for research in epilepsy-related neurological disorders.

For research use only. We do not sell to patients.

Nirvanol Chemical Structure

CAS No. : 631-07-2

Size	Price	Stock	Quantity
5 mg	USD 66	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 102	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Other Forms of Nirvanol:

Nirvanol-d₅ Get quote

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Purity & Documentation
References
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Description

Molecular Weight

204.23

Formula

C₁₁H₁₂N₂O₂

CAS No.

631-07-2

Appearance

Solid

Color

White to light yellow

SMILES

O=C1NC(C(C2=CC=CC=C2)(CC)N1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (244.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.8964 mL	24.4822 mL	48.9644 mL
5 mM	0.9793 mL	4.8964 mL	9.7929 mL
10 mM	0.4896 mL	2.4482 mL	4.8964 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (254 KB)

Handling Instructions (2659 KB)

References

[1]. Kupferberg HJ, et al. The metabolism of 3-methyl-5-ethyl-5-phenylhydantoin (mephenytoin) to 5-ethyl-5-phenylhydantoin (Nirvanol) in mice in relation to anticonvulsant activity. Drug Metab Dispos. 1975 Jan-Feb;3(1):26-9. PMID: 234831. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.8964 mL	24.4822 mL	48.9644 mL	122.4110 mL
	5 mM	0.9793 mL	4.8964 mL	9.7929 mL	24.4822 mL
	10 mM	0.4896 mL	2.4482 mL	4.8964 mL	12.2411 mL
	15 mM	0.3264 mL	1.6321 mL	3.2643 mL	8.1607 mL
	20 mM	0.2448 mL	1.2241 mL	2.4482 mL	6.1206 mL
	25 mM	0.1959 mL	0.9793 mL	1.9586 mL	4.8964 mL
	30 mM	0.1632 mL	0.8161 mL	1.6321 mL	4.0804 mL
	40 mM	0.1224 mL	0.6121 mL	1.2241 mL	3.0603 mL
	50 mM	0.0979 mL	0.4896 mL	0.9793 mL	2.4482 mL
	60 mM	0.0816 mL	0.4080 mL	0.8161 mL	2.0402 mL
	80 mM	0.0612 mL	0.3060 mL	0.6121 mL	1.5301 mL
	100 mM	0.0490 mL	0.2448 mL	0.4896 mL	1.2241 mL

Nirvanol Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nirvanol631-07-2Ethylphenylhydantoin Phenylethyihydantoin DesmethylmephenytoinDrug MetaboliteInhibitorinhibitorinhibit

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