Nitrocaramiphen hydrochloride

Cat. No.: HY-100945 Purity: 99.62%: FAQs
Data Sheet SDS COA Handling Instructions

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Nitrocaramiphen hydrochloride is a selective M1 receptor antagonist (K_i: 5.5 nM). Nitrocaramiphen Hydrochloride inhibits the hyperpolarizing effect of muscarine in the muscle fibers.

For research use only. We do not sell to patients.

Nitrocaramiphen hydrochloride Chemical Structure

CAS No. : 98636-73-8

Size	Price	Stock	Quantity
5 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 140	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Nitrocaramiphen hydrochloride is a selective M1 receptor antagonist (K_i: 5.5 nM). Nitrocaramiphen Hydrochloride inhibits the hyperpolarizing effect of muscarine in the muscle fibers^[1]^[2]^[3].

IC₅₀ & Target

Ki: 5.5 nM (M1 receptor)^[2]

Molecular Weight

370.87

Formula

C₁₈H₂₇ClN₂O₄

CAS No.

98636-73-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1(C2=CC=C([N+]([O-])=O)C=C2)CCCC1)OCCN(CC)CC.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 10 mg/mL (26.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 8.33 mg/mL (22.46 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6964 mL	13.4818 mL	26.9636 mL
5 mM	0.5393 mL	2.6964 mL	5.3927 mL
10 mM	0.2696 mL	1.3482 mL	2.6964 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.62%

Select Batch:

Data Sheet (277 KB) SDS (251 KB)

COA (256 KB) HNMR (249 KB) LCMS (92 KB)

Handling Instructions (2659 KB)

References

[1]. Hussain RI, et al. Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation. Br J Pharmacol. 2009 Feb;156(4):575-86. [Content Brief]

[2]. Hudkins RL, et al. Caramiphen, iodocaramiphen and nitrocaramiphen are potent, competitive, muscarinic M1 receptor-selective agents. Eur J Pharmacol. 1993 Feb 16;231(3):485-8. [Content Brief]

[3]. Naumenko NV, et al. [Pharmacological parameters of muscarinic cholinoreceptors in skeletal muscles]. Ross Fiziol Zh Im I M Sechenova. 2002 May;88(5):619-26. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	2.6964 mL	13.4818 mL	26.9636 mL	67.4091 mL
	5 mM	0.5393 mL	2.6964 mL	5.3927 mL	13.4818 mL
	10 mM	0.2696 mL	1.3482 mL	2.6964 mL	6.7409 mL
	15 mM	0.1798 mL	0.8988 mL	1.7976 mL	4.4939 mL
	20 mM	0.1348 mL	0.6741 mL	1.3482 mL	3.3705 mL
DMSO	25 mM	0.1079 mL	0.5393 mL	1.0785 mL	2.6964 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.