1. Anti-infection
  2. Antibiotic Bacterial
  3. Nitrofurantoin sodium

Nitrofurantoin sodium is a potent and orally active antibacterial agent. Nitrofurantoin sodium acts as an antibiotic. Nitrofurantoin sodium can be used for the study of urinary tract infections (UTIs), including cystitis and kidney infections.

For research use only. We do not sell to patients.

Nitrofurantoin sodium Chemical Structure

Nitrofurantoin sodium Chemical Structure

CAS No. : 54-87-5

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Description

Nitrofurantoin sodium is a potent and orally active antibacterial agent. Nitrofurantoin sodium acts as an antibiotic. Nitrofurantoin sodium can be used for the study of urinary tract infections (UTIs), including cystitis and kidney infections[1][2].

In Vitro

Nitrofurantoin sodium (0-512 mg/L; 8 h) treatment inhibits the growth of E. coli isolates[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: E. coli isolates: DA10708, DA13815, DA13824, DA13957, DA13992, DA10626, DA10627
Concentration: 0, 32, 64, 128, 256, and 512 mg/L
Incubation Time: 8 hours
Result: Observed bactericidal effect at 32 mg/L For DA10708, DA13815 and DA13824.
Inhibited the growth of DA13957 and DA13992 completely at 128 mg/L, observed bactericidal effect at 256 mg/L.
Showed a moderate killing at >128 mg/L for DA10626 and DA10627.
In Vivo

1.19 Nitrofurantoin pharmacokinetic effects in SD Rats[4].

Parameters 10 mg/kg p.o. 2 mg/kg i.v.
AUC0-720 (μg/mL•min) 306
AUC0-120 (μg/mL•min) 90.3
AUC0-∞ (μg/mL•min) 344 91.5
Cmax (μg/mL) 1.01
CL/F or CL (ml/min/kg) 31.0 22.7
t1/2 (min) 166 23.6
Bioavailability (%) 60.1

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

261.15

Formula

C8H6N4NaO5

CAS No.
SMILES

O=C1NC(CN1/N=C/C2=CC=C([N+]([O-])=O)O2)=O.[Na]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Nitrofurantoin sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Nitrofurantoin sodium
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HY-A0090A
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