2. Metabolic Enzyme/Protease GPCR/G Protein
  3. Endogenous Metabolite Angiotensin Receptor
  4. Nitrosoglutathione

Nitrosoglutathione  (Synonyms: GSNO; RVC-588; S-Nitroso-L-glutathione)

Cat. No.: HY-D0845 Purity: 90.56%
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Nitrosoglutathione (GSNO), a exogenous NO donor and a substrate for rat alcohol dehydrogenase class III isoenzyme, inhibits cerebrovascular angiotensin II-dependent and -independent AT1 receptor responses.

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Nitrosoglutathione Chemical Structure

Nitrosoglutathione Chemical Structure

CAS No. : 57564-91-7

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Based on 1 publication(s) in Google Scholar

Nitrosoglutathione Related Antibodies

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Description

Nitrosoglutathione (GSNO), a exogenous NO donor and a substrate for rat alcohol dehydrogenase class III isoenzyme, inhibits cerebrovascular angiotensin II-dependent and -independent AT1 receptor responses[1][2][3][4].

IC50 & Target

AT1 Receptor

 

Human Endogenous Metabolite

 

In Vitro

Nitrosoglutathione (GSNO, 250 μM) prevents 90% of the response to 0.1 μM 5-HT and 40% of the response to 1.0 μM 5-HT in rings treated with LY-83583, indicating an effect of GSNO that was independent of guanylate cyclase activity[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nitrosoglutathione Related Antibodies
In Vivo

Nitrosoglutathione (GSNO, 8 mg/kg) significantly decreases systolic, diastolic, and mean arterial pressures in PE-induced rats from day 14 through day 20[3].
Nitrosoglutathione (GSNO, 0.2 and 0.6 mg/kg) significantly inhibits superoxide production and suppressed NF-κB activation, iNOS induction, and 3-nitrotyrosine expression, but up-regulates endothelial NOS expression in the flap vessels[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Lewis rats[4].
Dosage: 0.2 and 0.6 mg/kg.
Administration: Slow intravenous injection via the opposite femoral vein into each rat.
Result: Animals treated with 0.2 mg of GSNO per kilogram before reperfusion had an intermediate survival rate (40.2 ± 4.9%). Although 0.6 mg/kg of GSNO showed a better rescuing effect than 150 mg/kg of NAC, there was no significant difference between the groups.
Clinical Trial
Molecular Weight

336.32

Formula

C10H16N4O7S
CAS No.
Appearance

Solid

Color

Pink to red

SMILES

OC(CNC([C@H](CSN=O)NC(CC[C@H](N)C(O)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 16.67 mg/mL (49.57 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9734 mL 14.8668 mL 29.7336 mL
5 mM 0.5947 mL 2.9734 mL 5.9467 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 90.56%

SDS (480 KB)

COA (245 KB) HNMR (195 KB) RP-HPLC (2110 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.9734 mL 14.8668 mL 29.7336 mL 74.3340 mL
5 mM 0.5947 mL 2.9734 mL 5.9467 mL 14.8668 mL
10 mM 0.2973 mL 1.4867 mL 2.9734 mL 7.4334 mL
15 mM 0.1982 mL 0.9911 mL 1.9822 mL 4.9556 mL
20 mM 0.1487 mL 0.7433 mL 1.4867 mL 3.7167 mL
25 mM 0.1189 mL 0.5947 mL 1.1893 mL 2.9734 mL
30 mM 0.0991 mL 0.4956 mL 0.9911 mL 2.4778 mL
40 mM 0.0743 mL 0.3717 mL 0.7433 mL 1.8583 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Nitrosoglutathione Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nitrosoglutathione57564-91-7GSNO RVC-588 S-Nitroso-L-glutathioneRVC588RVC 588RVC-588Endogenous MetaboliteAngiotensin ReceptorischemiaantioxidantI/RinjurysuperoxideNOInhibitorinhibitorinhibit

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