2. GPCR/G Protein
  3. GCGR
  4. NNC 92-1687

NNC 92-1687 is a non-peptide competitive human glucagon receptor antagonist (IC50=20 μM; Ki=9.1 μM). NNC 92-1687 can be used in the research of type 2 diabetes.

For research use only. We do not sell to patients.

NNC 92-1687 Chemical Structure

NNC 92-1687 Chemical Structure

CAS No. : 22903-37-3

Size Price Stock Quantity
1 mg USD 480 In-stock
5 mg USD 1060 In-stock
10 mg USD 1590 In-stock
25 mg USD 2670 In-stock
50 mg USD 3730 In-stock
100 mg USD 5030 In-stock
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500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

NNC 92-1687 Related Antibodies

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Description

NNC 92-1687 is a non-peptide competitive human glucagon receptor antagonist (IC50=20 μM; Ki=9.1 μM). NNC 92-1687 can be used in the research of type 2 diabetes[1].

Molecular Weight

300.33

Formula

C15H12N2O3S
CAS No.
Appearance

Solid

Color

Off-white to gray

SMILES

O=C(CSC1=NC2=C(N1)C=CC=C2)C3=CC=C(C(O)=C3)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (332.97 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3297 mL 16.6484 mL 33.2967 mL
5 mM 0.6659 mL 3.3297 mL 6.6593 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 5 mg/mL (16.65 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3297 mL 16.6484 mL 33.2967 mL 83.2418 mL
5 mM 0.6659 mL 3.3297 mL 6.6593 mL 16.6484 mL
10 mM 0.3330 mL 1.6648 mL 3.3297 mL 8.3242 mL
15 mM 0.2220 mL 1.1099 mL 2.2198 mL 5.5495 mL
20 mM 0.1665 mL 0.8324 mL 1.6648 mL 4.1621 mL
25 mM 0.1332 mL 0.6659 mL 1.3319 mL 3.3297 mL
30 mM 0.1110 mL 0.5549 mL 1.1099 mL 2.7747 mL
40 mM 0.0832 mL 0.4162 mL 0.8324 mL 2.0810 mL
50 mM 0.0666 mL 0.3330 mL 0.6659 mL 1.6648 mL
60 mM 0.0555 mL 0.2775 mL 0.5549 mL 1.3874 mL
80 mM 0.0416 mL 0.2081 mL 0.4162 mL 1.0405 mL
100 mM 0.0333 mL 0.1665 mL 0.3330 mL 0.8324 mL
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NNC 92-1687 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NNC 92-168722903-37-3GCGRGlucagon ReceptorCompetitiveAntagonistDiabetesGlucagonInhibitorinhibitorinhibit

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