2. Immunology/Inflammation
  3. NO Synthase
  4. NOS-IN-1

NOS-IN-1 is a potent and orally active NO synthase (NOS) isoforms inhibitor with IC50s of 0.1 μM, 1.1 μM, and 0.2 μM for human iNOS (hiNOS), heNOS and hnNOS, respectively.

For research use only. We do not sell to patients.

NOS-IN-1 Chemical Structure

NOS-IN-1 Chemical Structure

CAS No. : 165383-72-2

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Based on 1 publication(s) in Google Scholar

NOS-IN-1 Related Antibodies

Top Publications Citing Use of Products

View All NO Synthase Isoform Specific Products:

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nNOS iNOS eNOS

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

NOS-IN-1 is a potent and orally active NO synthase (NOS) isoforms inhibitor with IC50s of 0.1 μM, 1.1 μM, and 0.2 μM for human iNOS (hiNOS), heNOS and hnNOS, respectively[1].

IC50 & Target

IC50: 0.1 μM (hiNOS), 1.1 μM (heNOS), and 0.2 μM (hnNOS)[1]
In Vivo

Following oral administration, NOS-IN-1 (compound 3; 10 mg/kg) decreases serum nitrite/nitrate levels in an in vivo rat endotoxin assay[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

172.22

Formula

C8H16N2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC1=NCCC(C)C1.CC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 6.5 mg/mL (37.74 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.8065 mL 29.0326 mL 58.0653 mL
5 mM 1.1613 mL 5.8065 mL 11.6131 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.8065 mL 29.0326 mL 58.0653 mL 145.1632 mL
5 mM 1.1613 mL 5.8065 mL 11.6131 mL 29.0326 mL
10 mM 0.5807 mL 2.9033 mL 5.8065 mL 14.5163 mL
15 mM 0.3871 mL 1.9355 mL 3.8710 mL 9.6775 mL
20 mM 0.2903 mL 1.4516 mL 2.9033 mL 7.2582 mL
25 mM 0.2323 mL 1.1613 mL 2.3226 mL 5.8065 mL
30 mM 0.1936 mL 0.9678 mL 1.9355 mL 4.8388 mL
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NOS-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NOS-IN-1165383-72-2NO SynthaseNitric oxide synthasesNOSiNOSeNOSnNOSoralnitritenitrateInhibitorinhibitorinhibit

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