NOTA-bis(tBu)ester (Synonyms: NOTA-bis(t-Butyl ester))

Cat. No.: HY-W250574: FAQs
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NOTA-bis(tBu)ester (NOTA-bis(t-Butyl ester)), a NOTA derivative, is a bifunctional chelator that can be used for drug coupling.

For research use only. We do not sell to patients.

NOTA-bis(tBu)ester Chemical Structure

CAS No. : 1161415-28-6

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5 mg	USD 50	Ask For Quote & Lead Time
10 mg	USD 80	Ask For Quote & Lead Time
25 mg	USD 160	Ask For Quote & Lead Time
50 mg	USD 260	Ask For Quote & Lead Time
100 mg	USD 380	Ask For Quote & Lead Time

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Description

NOTA-bis(tBu)ester (NOTA-bis(t-Butyl ester)), a NOTA derivative, is a bifunctional chelator that can be used for drug coupling^[1].

IC₅₀ & Target

RDC Bifunctional Chelator

Molecular Weight

415.52

Formula

C₂₀H₃₇N₃O₆

CAS No.

1161415-28-6

Appearance

Solid

Color

White to light yellow

SMILES

O=C(CN1CCN(CCN(CC1)CC(OC(C)(C)C)=O)CC(OC(C)(C)C)=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Haojun Chen, et al. Novel "Add-On" Molecule Based on Evans Blue Confers Superior Pharmacokinetics and Transforms Drugs to Theranostic Agents. J Nucl Med. 2017 Apr;58(4):590-597. [Content Brief]

NOTA-bis(tBu)ester Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NOTA-bis(tBu)ester1161415-28-6NOTA-bis(t-Butyl ester)Radionuclide-Drug Conjugates (RDCs)Biochemical Assay ReagentsNOTA derivativebifunctional chelatorInhibitorinhibitorinhibit

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