2. Antibody-drug Conjugate/ADC Related
  3. Radionuclide-Drug Conjugates (RDCs)
  4. NOTA

NOTA is a bifunctional chelate which acts as the framework to construct PET imaging tools. NOTA also can be used for probe design and signal amplification via the multivalent effect.

For research use only. We do not sell to patients.

NOTA Chemical Structure

NOTA Chemical Structure

CAS No. : 56491-86-2

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5 mg USD 71 In-stock
10 mg USD 114 In-stock
25 mg USD 227 In-stock
50 mg USD 360 In-stock
100 mg USD 540 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of NOTA:

NOTA Related Antibodies

Top Publications Citing Use of Products

View All Radionuclide-Drug Conjugates (RDCs) Isoform Specific Products:

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RDC Peptide RDC Antibody RDC Bifunctional Chelator RDC Linker Other

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

NOTA is a bifunctional chelate which acts as the framework to construct PET imaging tools. NOTA also can be used for probe design and signal amplification via the multivalent effect[1][2].

IC50 & Target

RDC Bifunctional Chelator

 

Molecular Weight

303.31

Formula

C12H21N3O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (412.12 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2970 mL 16.4848 mL 32.9696 mL
5 mM 0.6594 mL 3.2970 mL 6.5939 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (329.70 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.2970 mL 16.4848 mL 32.9696 mL 82.4239 mL
5 mM 0.6594 mL 3.2970 mL 6.5939 mL 16.4848 mL
10 mM 0.3297 mL 1.6485 mL 3.2970 mL 8.2424 mL
15 mM 0.2198 mL 1.0990 mL 2.1980 mL 5.4949 mL
20 mM 0.1648 mL 0.8242 mL 1.6485 mL 4.1212 mL
25 mM 0.1319 mL 0.6594 mL 1.3188 mL 3.2970 mL
30 mM 0.1099 mL 0.5495 mL 1.0990 mL 2.7475 mL
40 mM 0.0824 mL 0.4121 mL 0.8242 mL 2.0606 mL
50 mM 0.0659 mL 0.3297 mL 0.6594 mL 1.6485 mL
60 mM 0.0549 mL 0.2747 mL 0.5495 mL 1.3737 mL
80 mM 0.0412 mL 0.2061 mL 0.4121 mL 1.0303 mL
100 mM 0.0330 mL 0.1648 mL 0.3297 mL 0.8242 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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NOTA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NOTA56491-86-2Radionuclide-Drug Conjugates (RDCs)bifunctional chelateframeworkPET imaging toolprobe designsignal amplificationInhibitorinhibitorinhibit

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