2. Metabolic Enzyme/Protease
  3. Thrombin
  4. NP-313

NP-313 is a potent antithrombotic agent that inhibits platelet aggregation and activation. NP-313 has dual inhibition of thromboxane A 2 synthesis and selective inhibition of SOCC-mediated Ca2+ inward flow.

For research use only. We do not sell to patients.

NP-313 Chemical Structure

NP-313 Chemical Structure

CAS No. : 5397-78-4

Size Price Stock Quantity
5 mg USD 150 In-stock
10 mg USD 240 In-stock
25 mg USD 480 In-stock
50 mg USD 770 In-stock
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

NP-313 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

NP-313 is a potent antithrombotic agent that inhibits platelet aggregation and activation. NP-313 has dual inhibition of thromboxane A 2 synthesis and selective inhibition of SOCC-mediated Ca2+ inward flow[1].

Cellular Effect
Cell Line Type Value Description References
MCF7 IC50
1.7 μM
Compound: 5
Antiproliferative activity against ERalpha positive human MCF7 cells after 72 hrs by MTS/PMS assay
Antiproliferative activity against ERalpha positive human MCF7 cells after 72 hrs by MTS/PMS assay
[PMID: 19101151]
SK-BR-3 IC50
0.6 μM
Compound: 5
Antiproliferative activity against ERalpha negative/Her2 over expressing human SKBR3 cells after 72 hrs by MTS/PMS assay
Antiproliferative activity against ERalpha negative/Her2 over expressing human SKBR3 cells after 72 hrs by MTS/PMS assay
[PMID: 19101151]
SK-BR-3 IC50
6.6 μM
Compound: 5
Inhibition of Hsp90 in human SKBR3 cells assessed as down-regulation of Her2 protein by ELISA
Inhibition of Hsp90 in human SKBR3 cells assessed as down-regulation of Her2 protein by ELISA
[PMID: 19101151]
In Vitro

NP-313 (0-80 μM) inhibits platelet aggregation in a dose-dependent manner. The maximum inhibition of platelet aggregation induced by thrombin and A23187 was approximately 80% and 60%, respectively[1].
NP-313 (0-8 μM) concentration-dependently inhibited P-selectin expression and thromboxane B 2 (TXB2) production in human platelets induced by collagen or thrombin. Also, NP-313 inhibited COX-1 and TXA 2 synthase with the IC 50 values of 1.5 and 3.9 µM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NP-313 Related Antibodies
In Vivo

NP-313 (i.v., 4-16 µg/g) significantly prolongs occlusion time (TTO), prolongs bleeding time and inhibits platelet aggregation induced by collagen (10 µg/mL) in male ICR mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

249.65

Formula

C12H8ClNO3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC(NC(C1=O)=C(Cl)C(C2=C1C=CC=C2)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (100.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0056 mL 20.0280 mL 40.0561 mL
5 mM 0.8011 mL 4.0056 mL 8.0112 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0056 mL 20.0280 mL 40.0561 mL 100.1402 mL
5 mM 0.8011 mL 4.0056 mL 8.0112 mL 20.0280 mL
10 mM 0.4006 mL 2.0028 mL 4.0056 mL 10.0140 mL
15 mM 0.2670 mL 1.3352 mL 2.6704 mL 6.6760 mL
20 mM 0.2003 mL 1.0014 mL 2.0028 mL 5.0070 mL
25 mM 0.1602 mL 0.8011 mL 1.6022 mL 4.0056 mL
30 mM 0.1335 mL 0.6676 mL 1.3352 mL 3.3380 mL
40 mM 0.1001 mL 0.5007 mL 1.0014 mL 2.5035 mL
50 mM 0.0801 mL 0.4006 mL 0.8011 mL 2.0028 mL
60 mM 0.0668 mL 0.3338 mL 0.6676 mL 1.6690 mL
80 mM 0.0501 mL 0.2504 mL 0.5007 mL 1.2518 mL
100 mM 0.0401 mL 0.2003 mL 0.4006 mL 1.0014 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

NP-313 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NP-3135397-78-4NP313NP 313Thrombinantithromboticplatelet aggregationthromboxane A 2 Ca2+SOCCInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
NP-313
Cat. No.:
HY-129496
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (419 KB) Français - FR (419 KB) Deutsch - DE (419 KB) Norwegian - NO (419 KB) Español - ES (419 KB) Swedish - SV (419 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.