2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. NS-102

NS-102 is a selective kainate (GluK2) receptor antagonist. NS-102 is a potent GluR6/7 receptor antagonist.

For research use only. We do not sell to patients.

NS-102 Chemical Structure

NS-102 Chemical Structure

CAS No. : 136623-01-3

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1 mg USD 192 In-stock
5 mg USD 480 In-stock
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100 mg USD 3600 In-stock
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Based on 1 publication(s) in Google Scholar

NS-102 Related Antibodies

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AMPA Receptor NMDA Receptor Kainate Receptor

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Description

NS-102 is a selective kainate (GluK2) receptor antagonist. NS-102 is a potent GluR6/7 receptor antagonist[1][2][3].

In Vitro

Combination of NS-102 (10 μM) and GYKI 52466 (30 μM) preventes full loss of compound action potentials (CAPs) during oxygen and glucose deprivation (OGD) and increases CAP area recovery[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NS-102 Related Antibodies
In Vivo

NS-102 (20, 40 or 80 μmol/litre ; in the hippocampal CA3 region) significantly reduces Sevoflurane-induced hyperactivities[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

261.23

Formula

C12H11N3O4
CAS No.
Appearance

Solid

Color

Off-white to yellow

SMILES

O=C1NC2=C(C=C([N+]([O-])=O)C3=C2CCCC3)/C1=N/O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 4 mg/mL (15.31 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8280 mL 19.1402 mL 38.2804 mL
5 mM 0.7656 mL 3.8280 mL 7.6561 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.23%

COA (255 KB) HNMR (109 KB) RP-HPLC (204 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8280 mL 19.1402 mL 38.2804 mL 95.7011 mL
5 mM 0.7656 mL 3.8280 mL 7.6561 mL 19.1402 mL
10 mM 0.3828 mL 1.9140 mL 3.8280 mL 9.5701 mL
15 mM 0.2552 mL 1.2760 mL 2.5520 mL 6.3801 mL
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NS-102 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NS-102136623-01-3NS102NS 102iGluRIonotropic glutamate receptorskainateGluK2GluR6/7Inhibitorinhibitorinhibit

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