NSC727447

Cat. No.: HY-W028350 Purity: ≥95.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

NSC727447 is an inhibitor of ribonuclease H (Rnase H) of HIV-1 and HIV-2. NSC727447 has little activity against E. coli RNase H, but great selectivity over human Rnase H, with IC₅₀s value of 2.0 μM, 2.5 μM, 100 μM, 10.6 μM, respectively.

For research use only. We do not sell to patients.

NSC727447 Chemical Structure

CAS No. : 40106-12-5

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 82	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 82	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 75	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 390	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 620	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

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HIV HIV-1 HIV-2

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
CEM-SS	CC₅₀	19.9 μM Compound: 1	Cytotoxicity against human CEM-SS cells by XTT assay Cytotoxicity against human CEM-SS cells by XTT assay	[PMID: 20547794]
CEM-SS	IC₅₀	4.3 μM Compound: 1	Antiviral activity against HIV-1 isolate RF infected in human CEM-SS cells assessed as inhibition of virus induced cytopathic effect by XTT assay Antiviral activity against HIV-1 isolate RF infected in human CEM-SS cells assessed as inhibition of virus induced cytopathic effect by XTT assay	[PMID: 20547794]

Molecular Weight

210.30

Formula

C₁₀H₁₄N₂OS

CAS No.

40106-12-5

Appearance

Solid

Color

Light brown to brown

SMILES

O=C(C1=C(N)SC2=C1CCCCC2)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (237.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.7551 mL	23.7756 mL	47.5511 mL
5 mM	0.9510 mL	4.7551 mL	9.5102 mL
10 mM	0.4755 mL	2.3776 mL	4.7551 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (273 KB) SDS (392 KB)

COA (253 KB) HNMR (238 KB) MS (70 KB)

Handling Instructions (2659 KB)

References

[1]. Michaela Wendeler, et al. Vinylogous Ureas as a Novel Class of Inhibitors of Reverse Transcriptase-Associated Ribonuclease H Activity. ACS Chem Biol. 2008 Oct 17;3(10):635-44. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.7551 mL	23.7756 mL	47.5511 mL	118.8778 mL
	5 mM	0.9510 mL	4.7551 mL	9.5102 mL	23.7756 mL
	10 mM	0.4755 mL	2.3776 mL	4.7551 mL	11.8878 mL
	15 mM	0.3170 mL	1.5850 mL	3.1701 mL	7.9252 mL
	20 mM	0.2378 mL	1.1888 mL	2.3776 mL	5.9439 mL
	25 mM	0.1902 mL	0.9510 mL	1.9020 mL	4.7551 mL
	30 mM	0.1585 mL	0.7925 mL	1.5850 mL	3.9626 mL
	40 mM	0.1189 mL	0.5944 mL	1.1888 mL	2.9719 mL
	50 mM	0.0951 mL	0.4755 mL	0.9510 mL	2.3776 mL
	60 mM	0.0793 mL	0.3963 mL	0.7925 mL	1.9813 mL
	80 mM	0.0594 mL	0.2972 mL	0.5944 mL	1.4860 mL
	100 mM	0.0476 mL	0.2378 mL	0.4755 mL	1.1888 mL

NSC727447 Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC72744740106-12-5NSC 727447NSC-727447DNA/RNA SynthesisHIVHuman immunodeficiency virusInhibitorinhibitorinhibit

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