2. Anti-infection Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis HIV
  4. NSC727447

NSC727447 is an inhibitor of ribonuclease H (Rnase H) of HIV-1 and HIV-2. NSC727447 has little activity against E. coli RNase H, but great selectivity over human Rnase H, with IC50s value of 2.0 μM, 2.5 μM, 100 μM, 10.6 μM, respectively.

For research use only. We do not sell to patients.

NSC727447 Chemical Structure

NSC727447 Chemical Structure

CAS No. : 40106-12-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 82 In-stock
Solution
10 mM * 1 mL in DMSO USD 82 In-stock
Solid
5 mg USD 75 In-stock
10 mg USD 120 In-stock
25 mg USD 240 In-stock
50 mg USD 390 In-stock
100 mg USD 620 In-stock
200 mg   Get quote  
500 mg   Get quote  

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NSC727447 Related Antibodies

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Description

NSC727447 is an inhibitor of ribonuclease H (Rnase H) of HIV-1 and HIV-2. NSC727447 has little activity against E. coli RNase H, but great selectivity over human Rnase H, with IC50s value of 2.0 μM, 2.5 μM, 100 μM, 10.6 μM, respectively[1].

Molecular Weight

210.30

Formula

C10H14N2OS
CAS No.
Appearance

Solid

Color

Light brown to brown

SMILES

O=C(C1=C(N)SC2=C1CCCCC2)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (237.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7551 mL 23.7756 mL 47.5511 mL
5 mM 0.9510 mL 4.7551 mL 9.5102 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥95.0%

COA (253 KB) HNMR (238 KB) MS (70 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.7551 mL 23.7756 mL 47.5511 mL 118.8778 mL
5 mM 0.9510 mL 4.7551 mL 9.5102 mL 23.7756 mL
10 mM 0.4755 mL 2.3776 mL 4.7551 mL 11.8878 mL
15 mM 0.3170 mL 1.5850 mL 3.1701 mL 7.9252 mL
20 mM 0.2378 mL 1.1888 mL 2.3776 mL 5.9439 mL
25 mM 0.1902 mL 0.9510 mL 1.9020 mL 4.7551 mL
30 mM 0.1585 mL 0.7925 mL 1.5850 mL 3.9626 mL
40 mM 0.1189 mL 0.5944 mL 1.1888 mL 2.9719 mL
50 mM 0.0951 mL 0.4755 mL 0.9510 mL 2.3776 mL
60 mM 0.0793 mL 0.3963 mL 0.7925 mL 1.9813 mL
80 mM 0.0594 mL 0.2972 mL 0.5944 mL 1.4860 mL
100 mM 0.0476 mL 0.2378 mL 0.4755 mL 1.1888 mL
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NSC727447 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC72744740106-12-5NSC 727447NSC-727447DNA/RNA SynthesisHIVHuman immunodeficiency virusInhibitorinhibitorinhibit

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