2. JAK/STAT Signaling
  3. Pim
  4. NSC756093

NSC756093 is a potent inhibitor of the GBP1:PIM1 interaction. NSC756093 can potentially revert resistance to paclitaxel. NSC756093 can be used for ovarian cancer research.

For research use only. We do not sell to patients.

NSC756093 Chemical Structure

NSC756093 Chemical Structure

CAS No. : 1629908-92-4

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Based on 1 publication(s) in Google Scholar

NSC756093 Related Antibodies

Top Publications Citing Use of Products

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PIM1 PIM2 PIM3

  • Biological Activity

  • Purity & Documentation

  • References

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Description

NSC756093 is a potent inhibitor of the GBP1:PIM1 interaction. NSC756093 can potentially revert resistance to paclitaxel. NSC756093 can be used for ovarian cancer research[1].

Cellular Effect
Cell Line Type Value Description References
FaDu IC50
0.496 μM
Compound: SU093
Synergistic antiproliferative activity against human FADU cells assessed as reduction in colony formation unit followed by irradiation with 5 Gy IR and measured after 10 to 14 days by crystal violet staining based assay
Synergistic antiproliferative activity against human FADU cells assessed as reduction in colony formation unit followed by irradiation with 5 Gy IR and measured after 10 to 14 days by crystal violet staining based assay
[PMID: 31531203]
FaDu IC50
6.5 μM
Compound: SU093
Inhibition of colony formation in human FADU cells incubated for 10 to 14 days by crystal violet staining based assay
Inhibition of colony formation in human FADU cells incubated for 10 to 14 days by crystal violet staining based assay
[PMID: 31531203]
Molecular Weight

337.37

Formula

C20H19NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1OCC(N2CCO)=C1C(C3=CC=CC=C3)C4=C2C=C(OC)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (185.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9641 mL 14.8205 mL 29.6410 mL
5 mM 0.5928 mL 2.9641 mL 5.9282 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9641 mL 14.8205 mL 29.6410 mL 74.1026 mL
5 mM 0.5928 mL 2.9641 mL 5.9282 mL 14.8205 mL
10 mM 0.2964 mL 1.4821 mL 2.9641 mL 7.4103 mL
15 mM 0.1976 mL 0.9880 mL 1.9761 mL 4.9402 mL
20 mM 0.1482 mL 0.7410 mL 1.4821 mL 3.7051 mL
25 mM 0.1186 mL 0.5928 mL 1.1856 mL 2.9641 mL
30 mM 0.0988 mL 0.4940 mL 0.9880 mL 2.4701 mL
40 mM 0.0741 mL 0.3705 mL 0.7410 mL 1.8526 mL
50 mM 0.0593 mL 0.2964 mL 0.5928 mL 1.4821 mL
60 mM 0.0494 mL 0.2470 mL 0.4940 mL 1.2350 mL
80 mM 0.0371 mL 0.1853 mL 0.3705 mL 0.9263 mL
100 mM 0.0296 mL 0.1482 mL 0.2964 mL 0.7410 mL
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NSC756093 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC7560931629908-92-4SU093NSC 756093NSC-756093SU 093SU-093PimPim kinasesovarian cancerNCI-60 cellSKOV3 cellspaclitaxel resistantanticancerInhibitorinhibitorinhibit

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