2. JAK/STAT Signaling Stem Cell/Wnt Apoptosis Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. STAT Apoptosis Reactive Oxygen Species
  4. NW16

NW16 is an orally active inhibitor for STAT3 with Kd of 11.0 μM. NW16 arrests the cell cycle at S phase, induces apoptosis in HCT116, and inhibits the proliferation of cancer cell HCT116, A549, and B16 with IC50s of 0.28, 1.22, and 9.86 μM, respectively. NW16 induces the production of ROS, inhibits the PI3K/AKT signaling pathway, and thus exhibits antitumor efficacy in mouse model.

For research use only. We do not sell to patients.

NW16 Chemical Structure

NW16 Chemical Structure

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NW16 Related Antibodies

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Description

NW16 is an orally active inhibitor for STAT3 with Kd of 11.0 μM. NW16 arrests the cell cycle at S phase, induces apoptosis in HCT116, and inhibits the proliferation of cancer cell HCT116, A549, and B16 with IC50s of 0.28, 1.22, and 9.86 μM, respectively. NW16 induces the production of ROS, inhibits the PI3K/AKT signaling pathway, and thus exhibits antitumor efficacy in mouse model[1].

IC50 & Target

STAT3

11.0 μM (Kd)

Molecular Weight

336.30

Formula

C18H12N2O5
SMILES

N#C/C(C(NCCO)=O)=C\C1=CC2=C(O1)C(C3=CC=CC=C3C2=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NW16 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NW16NW 16NW-16STATApoptosisReactive Oxygen SpeciesHCT116orally activecolorectal cancerBALB/c mouseA549B16Inhibitorinhibitorinhibit

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