2. Immunology/Inflammation
  3. CD20 CD3
  4. Odronextamab

Odronextamab is a stable humanized IgG4 CD20 × CD3 bispecific antibody that binds to CD3 on T cells and CD20 on B cells, triggering anti-tumor activity. Odronextamab is expected to be used in oncology research.

For research use only. We do not sell to patients.

CAS No. : 1801338-64-6

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Description

Odronextamab is a stable humanized IgG4 CD20 × CD3 bispecific antibody that binds to CD3 on T cells and CD20 on B cells, triggering anti-tumor activity. Odronextamab is expected to be used in oncology research[1].

Isotype

Human IgG4 kappa
Recommend Isotype Controls
Species

Bispecific

In Vitro

Odronextamab (1-10 nM, 48-96 h) at a low picomolar concentration, mediates cytotoxicity of all tested CD20-expressing lymphoma cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Odronextamab Related Antibodies

Cell Cytotoxicity Assay[2]

Cell Line: Human peripheral blood mononuclear cells, CD20-expressing Nalm6 tumor cells
Concentration: 1-10 nM
Incubation Time: 48-96 h
Result: At a low picomolar concentration of was capable of mediating cytotoxicity of all CD20-expressing lymphoma cells tested; EC50 values for cytotoxicity were in a range of 3-25 pM.
In Vivo

Odronextamab (0.4-1 mg/kg, administered via intraperitoneal injection, single dose) exhibits dose-dependent tumor-suppressive activity in a mouse tumor model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Raji cell xenograft tumor mice model[2]
Dosage: 0.04, 0.1, 0.4, 1.0 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Treatment at doses of 0.4 or 1 mg/kg in mice resulted in complete tumor suppression. In mice receiving 0.04-0.1 mg/kg concentrations of odronextamab, tumor growth was slowed.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Odronextamab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Odronextamab1801338-64-6CD20CD3Cluster of differentiation 3hinge-stabilisedfully human IgG4-basedbispecific antibodyInhibitorinhibitorinhibit

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