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OGG1-IN-08 is a potent 8-oxoguanine DNA glycosylase-1 (OGG1) inhibitor with an IC50 value of 0.22 μM. OGG1-IN-08 decreases both the glycosylase and lyase activities of OGG1.

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OGG1-IN-08 Chemical Structure

OGG1-IN-08 Chemical Structure

CAS No. : 350997-39-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 66 In-stock
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Solid
1 mg USD 30 In-stock
5 mg USD 60 In-stock
10 mg USD 100 In-stock
25 mg USD 200 In-stock
50 mg USD 300 In-stock
100 mg USD 450 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

OGG1-IN-08 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE OGG1-IN-08

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

OGG1-IN-08 is a potent 8-oxoguanine DNA glycosylase-1 (OGG1) inhibitor with an IC50 value of 0.22 μM. OGG1-IN-08 decreases both the glycosylase and lyase activities of OGG1[1].

IC50 & Target

IC50: 0.22 μM (OGG1)[1]
In Vitro

OGG1-IN-08 (50 μM) inhibits different DNA glycosylases activities, it inhibits?nei endonuclease VIII-like 1 DNA glycosylase (NEIL1)(84.56%), endonuclease III-like (NTH1)(63.09%), and Fpg (91.74%), respectively[1].
OGG1-IN-08 (10 μM) has a inhibitory OGG1 lyase activity on a substrate containing an AP site compared with the no inhibitor control[1].
OGG1-IN-08 (10 μM) decreases the number of bases released into solution by OGG1 for both the 8-oxo-Gua and FapyGua compared with the no inhibitor[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

OGG1-IN-08 Related Antibodies
Molecular Weight

261.13

Formula

C9H6Cl2N2OS
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C(C1=C(Cl)C2=C(Cl)C=CC=C2S1)NN
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (95.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8295 mL 19.1476 mL 38.2951 mL
5 mM 0.7659 mL 3.8295 mL 7.6590 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.60%

COA (251 KB) HNMR (261 KB) RP-HPLC (254 KB) MS (69 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8295 mL 19.1476 mL 38.2951 mL 95.7378 mL
5 mM 0.7659 mL 3.8295 mL 7.6590 mL 19.1476 mL
10 mM 0.3830 mL 1.9148 mL 3.8295 mL 9.5738 mL
15 mM 0.2553 mL 1.2765 mL 2.5530 mL 6.3825 mL
20 mM 0.1915 mL 0.9574 mL 1.9148 mL 4.7869 mL
25 mM 0.1532 mL 0.7659 mL 1.5318 mL 3.8295 mL
30 mM 0.1277 mL 0.6383 mL 1.2765 mL 3.1913 mL
40 mM 0.0957 mL 0.4787 mL 0.9574 mL 2.3934 mL
50 mM 0.0766 mL 0.3830 mL 0.7659 mL 1.9148 mL
60 mM 0.0638 mL 0.3191 mL 0.6383 mL 1.5956 mL
80 mM 0.0479 mL 0.2393 mL 0.4787 mL 1.1967 mL
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OGG1-IN-08 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OGG1-IN-08350997-39-6OthersglycosylaselyaseOGG1AP site8-oxo-GuaFapyGuaInhibitorinhibitorinhibit

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