2. PROTAC
  3. Ligands for E3 Ligase
  4. OICR-8268-acrylic acid

OICR-8268-acrylic acid is a ligand for E3 ubiquitin ligase. OICR-8268-acrylic acid can be connected to the ligand for protein by a linker to form OICR41114 (HY-169389). OICR41114 can be used in anti-cancer research.

For research use only. We do not sell to patients.

OICR-8268-acrylic acid Chemical Structure

OICR-8268-acrylic acid Chemical Structure

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OICR-8268-acrylic acid Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1

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Description

OICR-8268-acrylic acid is a ligand for E3 ubiquitin ligase. OICR-8268-acrylic acid can be connected to the ligand for protein by a linker to form OICR41114 (HY-169389). OICR41114 can be used in anti-cancer research[1].

IC50 & Target

VHL

 

Molecular Weight

508.30

Formula

C23H17Cl2F2N3O4
SMILES

O=C(O)/C=C/C1=C(C(C(N[C@H](C2=CC=C(C(Cl)=C2)F)CC(N)=O)=O)=CN1)C3=C(C=C(C=C3)Cl)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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OICR-8268-acrylic acid Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OICR-8268-acrylic acidLigands for E3 LigaseE3 ligase-recruiting MoietyE3 ubiquitin ligaseOICR41114anti-cancerInhibitorinhibitorinhibit

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