Olpadronic acid (Synonyms: Olpadronate; OLP)

Cat. No.: HY-106431 Purity: ≥95.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Olpadronic acid (Olpadronate) is an orally active amino-bisphosphonate and inhibits bone resorption. Olpadronic acid also prevents bone destruction and tumor growth in the skeletal prostate cancer mouse model. Olpadronic acid can be used for research of osteoporosis, malignancies and rheumatoid arthritis.

For research use only. We do not sell to patients.

Olpadronic acid Chemical Structure

CAS No. : 63132-39-8

Size	Price	Stock	Quantity
5 mg	USD 275	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Description

Molecular Weight

263.12

Formula

C₅H₁₅NO₇P₂

CAS No.

63132-39-8

Appearance

Solid

Color

White to off-white

SMILES

O=P(O)(C(CCN(C)C)(P(O)(O)=O)O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (190.03 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8005 mL	19.0027 mL	38.0055 mL
5 mM	0.7601 mL	3.8005 mL	7.6011 mL
10 mM	0.3801 mL	1.9003 mL	3.8005 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (252 KB)

Handling Instructions (2659 KB)

References

[1]. Roldán EJ, et al. Olpadronate: a new amino-bisphosphonate for the treatment of medical osteopathies. Expert Opin Investig Drugs. 1998 Sep;7(9):1521-38. [Content Brief]

[2]. Yang M, et al. The bisphosphonate olpadronate inhibits skeletal prostate cancer progression in a green fluorescent protein nude mouse model. Clin Cancer Res. 2006 Apr 15;12(8):2602-6. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.8005 mL	19.0027 mL	38.0055 mL	95.0137 mL
	5 mM	0.7601 mL	3.8005 mL	7.6011 mL	19.0027 mL
	10 mM	0.3801 mL	1.9003 mL	3.8005 mL	9.5014 mL
	15 mM	0.2534 mL	1.2668 mL	2.5337 mL	6.3342 mL
	20 mM	0.1900 mL	0.9501 mL	1.9003 mL	4.7507 mL
	25 mM	0.1520 mL	0.7601 mL	1.5202 mL	3.8005 mL
	30 mM	0.1267 mL	0.6334 mL	1.2668 mL	3.1671 mL
	40 mM	0.0950 mL	0.4751 mL	0.9501 mL	2.3753 mL
	50 mM	0.0760 mL	0.3801 mL	0.7601 mL	1.9003 mL
	60 mM	0.0633 mL	0.3167 mL	0.6334 mL	1.5836 mL
	80 mM	0.0475 mL	0.2375 mL	0.4751 mL	1.1877 mL
	100 mM	0.0380 mL	0.1900 mL	0.3801 mL	0.9501 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Olpadronic acid Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Olpadronic acid63132-39-8Olpadronate OLPOthersbone diseaserheumatoid arthritisprostate cancerInhibitorinhibitorinhibit

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