2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Oncrasin-72

Oncrasin-72 (NSC-743380) is an RNA polymerase II inhibitor with activity in inhibiting growth and inducing cell death in human cancer cells. Oncrasin-72 exhibits antitumor activity through JNK activation and STAT3 inhibition. Analytical method development and validation for Oncrasin-72 is essential for quantifying its concentration in biological fluids for pharmacokinetic studies. This method was able to successfully quantify Oncrasin-72 in different dose groups when applied in rat plasma.

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Oncrasin-72 Chemical Structure

Oncrasin-72 Chemical Structure

CAS No. : 92407-90-4

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Oncrasin-72 Related Antibodies

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Description

Oncrasin-72 (NSC-743380) is an RNA polymerase II inhibitor with activity in inhibiting growth and inducing cell death in human cancer cells. Oncrasin-72 exhibits antitumor activity through JNK activation and STAT3 inhibition. Analytical method development and validation for Oncrasin-72 is essential for quantifying its concentration in biological fluids for pharmacokinetic studies. This method was able to successfully quantify Oncrasin-72 in different dose groups when applied in rat plasma[1].

Molecular Weight

271.74

Formula

C16H14ClNO
CAS No.
SMILES

ClC1=CC=CC(CN2C=C(CO)C3=C2C=CC=C3)=C1
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Purity & Documentation
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Oncrasin-72 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oncrasin-7292407-90-4NSC-743380Oncrasin72Oncrasin 72NSC743380NSC 743380Endogenous MetaboliteInhibitorinhibitorinhibit

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