2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. ONO 1301

ONO 1301  (Synonyms: ONO-AP 500-02)

Cat. No.: HY-106961 Purity: 99.06%
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ONO 1301 (ONO-AP 500-02), a prostaglandin (PG) I2 mimetic, is an orally active, long-acting prostacyclin agonist with thromboxane-synthase inhibitory activity. ONO 1301 promotes production of hepatocyte growth factor (HGF) from various cell types and ameliorates ischemia-induced left ventricle dysfunction in the mouse, rat and pig.

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ONO 1301 Chemical Structure

ONO 1301 Chemical Structure

CAS No. : 176391-41-6

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Based on 1 publication(s) in Google Scholar

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Description

ONO 1301 (ONO-AP 500-02), a prostaglandin (PG) I2 mimetic, is an orally active, long-acting prostacyclin agonist with thromboxane-synthase inhibitory activity. ONO 1301 promotes production of hepatocyte growth factor (HGF) from various cell types and ameliorates ischemia-induced left ventricle dysfunction in the mouse, rat and pig[1][2][3].

In Vitro

ONO 1301 (ONO-AP 500-02) inhibits collagen-induced aggregation in a concentration-dependent manner, with an IC50 value of 460 nM[3].
ONO-1301 (0-1000 nM) significantly increases alkaline phosphatase (ALP) activity in the primary osteoblasts and ST2 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ONO 1301 Related Antibodies
In Vivo

ONO-1301 (6 mg/kg; p.o.; /daily for 4 weeks) improves the hemodynamic status of rats with dilated cardiomyopathy after experimental autoimmune myocarditis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-week-old male Lewis rats (rat model of myosin-induced experimental autoimmune myocarditis)[1]
Dosage: 6 mg/kg
Administration: Orally; /daily for 4 weeks
Result: Hemodynamic parameters and plasma brain natriuretic peptide (BNP) level were significantly improved.
Molecular Weight

428.49

Formula

C26H24N2O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(COC1=C2C(C(CCO/N=C(C3=CN=CC=C3)\C4=CC=CC=C4)=CCC2)=CC=C1)=O.[(E)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (116.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3338 mL 11.6689 mL 23.3378 mL
5 mM 0.4668 mL 2.3338 mL 4.6676 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3338 mL 11.6689 mL 23.3378 mL 58.3444 mL
5 mM 0.4668 mL 2.3338 mL 4.6676 mL 11.6689 mL
10 mM 0.2334 mL 1.1669 mL 2.3338 mL 5.8344 mL
15 mM 0.1556 mL 0.7779 mL 1.5559 mL 3.8896 mL
20 mM 0.1167 mL 0.5834 mL 1.1669 mL 2.9172 mL
25 mM 0.0934 mL 0.4668 mL 0.9335 mL 2.3338 mL
30 mM 0.0778 mL 0.3890 mL 0.7779 mL 1.9448 mL
40 mM 0.0583 mL 0.2917 mL 0.5834 mL 1.4586 mL
50 mM 0.0467 mL 0.2334 mL 0.4668 mL 1.1669 mL
60 mM 0.0389 mL 0.1945 mL 0.3890 mL 0.9724 mL
80 mM 0.0292 mL 0.1459 mL 0.2917 mL 0.7293 mL
100 mM 0.0233 mL 0.1167 mL 0.2334 mL 0.5834 mL
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ONO 1301 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ONO 1301176391-41-6ONO-AP 500-02ONO1301ONO-1301Prostaglandin ReceptorthromboxaneHGFgrowthfactorhepatocyteischemialeftventricledysfunctionInhibitorinhibitorinhibit

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