2. Neuronal Signaling Protein Tyrosine Kinase/RTK
  3. Trk Receptor
  4. ONO-7579

ONO-7579 is an orally active TRKA inhibitor that suppresses tumor growth by inhibiting the phosphorylation of TRKA. In colorectal cancer cells KM12, its EC50 is 17.6 ng/g (meaning that when each gram of tumor tissue contains 17.6 ng of ONO-7579, the activity of phosphorylated TRKA in the tumor is inhibited by 50%). ONO-7579 can be used in cancer research.

For research use only. We do not sell to patients.

ONO-7579 Chemical Structure

ONO-7579 Chemical Structure

CAS No. : 1622212-25-2

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ONO-7579 Related Antibodies

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TrkA TrkB TrkC Trk

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Description

ONO-7579 is an orally active TRKA inhibitor that suppresses tumor growth by inhibiting the phosphorylation of TRKA. In colorectal cancer cells KM12, its EC50 is 17.6 ng/g (meaning that when each gram of tumor tissue contains 17.6 ng of ONO-7579, the activity of phosphorylated TRKA in the tumor is inhibited by 50%). ONO-7579 can be used in cancer research[1].

IC50 & Target

TrkA

 

Molecular Weight

578.95

Formula

C24H18ClF3N6O4S
CAS No.
SMILES

O=C(NC1=CC(C(F)(F)F)=CC=C1S(=O)(C)=O)NC2=CN=C(OC3=CC=C(C4=CC(Cl)=CN=C4N)C=C3)N=C2
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ONO-7579 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ONO-75791622212-25-2ONO7579ONO 7579Trk ReceptorTropomyosin related kinase receptorAnti-cancerInhibitorinhibitorinhibit

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