2. Neuronal Signaling
  3. Sigma Receptor
  4. Opipramol

Opipramol  (Synonyms: Ensidon; G-33040)

Cat. No.: HY-118901 Purity: 99.91%
COA Handling Instructions

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Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA). Opipramol acts primarily as a sigma (σ) receptor agonist and can potently interact with sigma recognition sites with a Ki value of 50 nM. Opipramol can be used for the research of generalized anxiety disorder (GAD).

For research use only. We do not sell to patients.

Opipramol Chemical Structure

Opipramol Chemical Structure

CAS No. : 315-72-0

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Based on 1 publication(s) in Google Scholar

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Opipramol Related Antibodies

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Description

Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA). Opipramol acts primarily as a sigma (σ) receptor agonist and can potently interact with sigma recognition sites with a Ki value of 50 nM. Opipramol can be used for the research of generalized anxiety disorder (GAD)[1][2].

IC50 & Target

Ki: 50 nM (σ receptor); IC50: 5.5 μM ([3H] DA)[1].
In Vitro

Opipramol can potently interact with sigma recognition sites with a Ki value of 50 nM[1].
Opipramol inhibit the uptake of [3H] DA in crude synaptosomal preparations with an IC50 value of 5.5 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Opipramol Related Antibodies
In Vivo

Opipramol (i.p.; 5-50 mg/kg) increases dopamine release in vivo[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats (male, 150-l 80 g)[2]
Dosage: 5-50 mg/kg
Administration: Intraperitoneal injections
Result: Increased the levels of DOPAC and HVA in the striatum of the rat, without changing the steady-state levels of DA.
Potently increased the metabolism of dopamine in the striatum, olfactory tubercle and pyriform cortex of the rat.
Increased plasma prolactin in the rat, only at a dose as large as 50 mg/kg dose.
Clinical Trial
Molecular Weight

363.50

Formula

C23H29N3O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

OCCN1CCN(CCCN2C3=CC=CC=C3C=CC4=CC=CC=C42)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (275.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7510 mL 13.7552 mL 27.5103 mL
5 mM 0.5502 mL 2.7510 mL 5.5021 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (6.88 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.91%

COA (250 KB) HNMR (263 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7510 mL 13.7552 mL 27.5103 mL 68.7758 mL
5 mM 0.5502 mL 2.7510 mL 5.5021 mL 13.7552 mL
10 mM 0.2751 mL 1.3755 mL 2.7510 mL 6.8776 mL
15 mM 0.1834 mL 0.9170 mL 1.8340 mL 4.5851 mL
20 mM 0.1376 mL 0.6878 mL 1.3755 mL 3.4388 mL
25 mM 0.1100 mL 0.5502 mL 1.1004 mL 2.7510 mL
30 mM 0.0917 mL 0.4585 mL 0.9170 mL 2.2925 mL
40 mM 0.0688 mL 0.3439 mL 0.6878 mL 1.7194 mL
50 mM 0.0550 mL 0.2751 mL 0.5502 mL 1.3755 mL
60 mM 0.0459 mL 0.2293 mL 0.4585 mL 1.1463 mL
80 mM 0.0344 mL 0.1719 mL 0.3439 mL 0.8597 mL
100 mM 0.0275 mL 0.1376 mL 0.2751 mL 0.6878 mL
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Opipramol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Opipramol315-72-0Ensidon G-33040G33040G 33040G-33040Sigma Receptorantidepressant (TCA)sigma (σ) receptorgeneralized anxiety disorder (GAD)Inhibitorinhibitorinhibit

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