Org-12962 hydrochloride

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Org 12962 hydrochloride is a potent, selective and efficacious 5-HT_2C receptor agonist and exhibits pEC₅₀ values of 7.01, 6.38 and 6.28 for 5-HT_2C, 5-HT_2A and 5-HT_2A, respectively. Org 12962 hydrochloride is effective in panic-like anxiety animal model.

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Org-12962 hydrochloride Chemical Structure

CAS No. : 210821-63-9

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Other Forms of Org-12962 hydrochloride:

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5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor 5-HT Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]^[2]

5-HT_2C Receptor

7.01 (pEC₅₀)

5-HT_2A Receptor

6.38 (pEC₅₀)

5-HT_2B Receptor

6.28 (pEC₅₀)

In Vivo

Org 12962 (intraperitoneal injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg) displays antiaversive effects in a rat model of panic-like anxiety, it increases the postinjection frequency thresholds for self-interruption (F_3.71=11.40). The dose of 0.3 mg/kg ip is not significantly active, that the dose of 1 mg/kg is marginally active and that 3.2 mg/kg ip induced highly significant antiaversive effects^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats^[3]
Dosage:	0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg
Administration:	Intraperitoneal injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg
Result:	Had a dose-related antipanic-like effect in SD-rat.

Molecular Weight

302.12

Formula

C₁₀H₁₂Cl₂F₃N₃

CAS No.

210821-63-9

SMILES

FC(C1=C(Cl)N=C(N2CCNCC2)C=C1)(F)F.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Porter RH,et al. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells.Br J Pharmacol. 1999 Sep;128(1):13-20. [Content Brief]

[2]. Jenck F, et al. Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats.Eur Neuropsychopharmacol. 1998 Aug;8(3):161-8. [Content Brief]

[3]. Faassen F, et al. Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.Int J Pharm. 2003 Sep 16;263(1-2):113-22. [Content Brief]