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Osivelotor  (Synonyms: GBT-601; GBT-021601)

Cat. No.: HY-148788 Purity: 99.83%
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Osivelotor is an orally effective small molecule. Osivelotor is an allosteric regulator of deoxyhemoglobin S (HbS). Osivelotor increases the affinity of HbS to oxygen, inhibits HbS polymerization, and thus prevents erythrocyte sickling in the blood. Osivelotor can be used for research of sickle cell disease (SCD) .

For research use only. We do not sell to patients.

Osivelotor Chemical Structure

Osivelotor Chemical Structure

CAS No. : 2417955-18-9

Size Price Stock Quantity
5 mg USD 750 In-stock
10 mg USD 1150 In-stock
25 mg USD 2350 In-stock
50 mg USD 3800 In-stock
100 mg USD 6200 In-stock
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Based on 1 publication(s) in Google Scholar

Osivelotor Related Antibodies

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Description

Osivelotor is an orally effective small molecule. Osivelotor is an allosteric regulator of deoxyhemoglobin S (HbS). Osivelotor increases the affinity of HbS to oxygen, inhibits HbS polymerization, and thus prevents erythrocyte sickling in the blood. Osivelotor can be used for research of sickle cell disease (SCD) [1] [2].

In Vivo

Osivelotor (20-150 mg/kg; Oral gavage; Once a day; 21 days) significantly improves red blood cell health, reduces red blood cell sickle response and maintains oxygen delivery to peripheral tissues in a mouse model of sickle cell disease [2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male knock-in Townes mice with an HbSS genotype [2]
Dosage: 20, 40, 75 and 150mg/kg
Administration: Oral gavage (i.g.); once a day; 21 days
Result: Reduced red blood cell sickling, improved red blood cell deformability and prolonged red blood cell half-life.
Restored haemoglobin levels to the normal range.
Improved oxygen delivery and increased tolerance to severe hypoxia.
Molecular Weight

386.40

Formula

C20H22N2O6
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(C1=C(N=CC=C1)CCO)N2[C@@H](COCC2)COC3=C(C(O)=CC=C3)C=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (258.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5880 mL 12.9400 mL 25.8799 mL
5 mM 0.5176 mL 2.5880 mL 5.1760 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5880 mL 12.9400 mL 25.8799 mL 64.6998 mL
5 mM 0.5176 mL 2.5880 mL 5.1760 mL 12.9400 mL
10 mM 0.2588 mL 1.2940 mL 2.5880 mL 6.4700 mL
15 mM 0.1725 mL 0.8627 mL 1.7253 mL 4.3133 mL
20 mM 0.1294 mL 0.6470 mL 1.2940 mL 3.2350 mL
25 mM 0.1035 mL 0.5176 mL 1.0352 mL 2.5880 mL
30 mM 0.0863 mL 0.4313 mL 0.8627 mL 2.1567 mL
40 mM 0.0647 mL 0.3235 mL 0.6470 mL 1.6175 mL
50 mM 0.0518 mL 0.2588 mL 0.5176 mL 1.2940 mL
60 mM 0.0431 mL 0.2157 mL 0.4313 mL 1.0783 mL
80 mM 0.0323 mL 0.1617 mL 0.3235 mL 0.8087 mL
100 mM 0.0259 mL 0.1294 mL 0.2588 mL 0.6470 mL
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Osivelotor Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Osivelotor2417955-18-9GBT-601 GBT-021601GBT601GBT 601GBT021601GBT 021601GBT-021601OthersHbSSickle cell diseaseTownes miceInhibitorinhibitorinhibit

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