2. Membrane Transporter/Ion Channel Neuronal Signaling Anti-infection
  3. nAChR Parasite
  4. Oxantel

Oxantel (CP-14445), a m-oxyphenol derivative of Pyrantel (HY-12641), is a N-subtype AChR agonist. Oxantel is an anthelmintic, with excellent trichuricidal properties.

For research use only. We do not sell to patients.

Oxantel Chemical Structure

Oxantel Chemical Structure

CAS No. : 36531-26-7

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Oxantel Related Antibodies

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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Description

Oxantel (CP-14445), a m-oxyphenol derivative of Pyrantel (HY-12641), is a N-subtype AChR agonist. Oxantel is an anthelmintic, with excellent trichuricidal properties[1][2].

IC50 & Target

nAChR[1][2]
In Vitro

Oxantel ( 0.015-600 µg/mL; 24-72 hours) reduces the viability of T. muris[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Oxantel Related Antibodies

Cell Viability Assay

Cell Line: T. muris
Concentration: 0.015 µg/mL, 0.3 µg/mL, 0.6 µg/mL, 4.66 µg/mL, 9.375 µg/mL, 150 µg/mL, 600 µg/mL
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Resulted in strongly reduced viabilities; resulted in strongly reduced viabilities within 24 hours but did not kill the worms.
In Vivo

Oxantel (1-10 mg/kg; i.p.) displays a high activity against T. muris in vivo, with an EC50 of 4.71 mg/kg[1].
Oxantel (10 mg/kg; i.p.) exhibits a worm burden reduction (WBR) of 92.5% and worm expulsion rate (WER) of 88.4% for T. muris[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4 week-old female C57BL/10 mice and 3 week-old male[1]
Dosage: 1 mg/kg, 2.5 mg/kg, 5 mg/kg, 10 mg/kg
Administration: Intraperitoneal injection
Result: Inhibited T. muris in vivo.
Clinical Trial
Molecular Weight

216.28

Formula

C13H16N2O
CAS No.
SMILES

OC1=CC=CC(/C=C/C2=NCCCN2C)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Oxantel Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oxantel36531-26-7CP-14445CP14445CP 14445nAChRParasiteNicotinic acetylcholine receptorsanthelminticwhipwormTrichurisinfectionsInhibitorinhibitorinhibit

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