2. Anti-infection Neuronal Signaling Membrane Transporter/Ion Channel
  3. Parasite nAChR Antibiotic
  4. Pyrantel pamoate

Pyrantel pamoate  (Synonyms: Pyrantel embonate)

Cat. No.: HY-12640 Purity: 99.94%
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Pyrantel pamoate (Pyrantel embonate) is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel pamoate can cause spasmodic muscle paralysis in parasites. Pyrantel pamoate can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis.

For research use only. We do not sell to patients.

Pyrantel pamoate Chemical Structure

Pyrantel pamoate Chemical Structure

CAS No. : 22204-24-6

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 33 In-stock
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10 mM * 1 mL in DMSO USD 33 In-stock
Solid
100 mg USD 30 In-stock
500 mg USD 75 In-stock
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Based on 2 publication(s) in Google Scholar

Other Forms of Pyrantel pamoate:

Pyrantel pamoate Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Pyrantel pamoate (Pyrantel embonate) is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel pamoate can cause spasmodic muscle paralysis in parasites. Pyrantel pamoate can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis[1][2].

IC50 & Target

Parasites[1][2].
In Vitro

Pyrantel pamoate (10 nM-10 μM; 72 h) shows good anti-A. suum and (0-168.2 M; 72 h) anti-N. americanus activity[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pyrantel pamoate Related Antibodies

Cell Viability Assay[1]

Cell Line: A. suum
Concentration: 10 nM-10 µM
Incubation Time: 72 h
Result: Inhibited A. suum with a pEC50 value of 7.24.

Cell Viability Assay[2]

Cell Line: N. americanus
Concentration: 0-168.2 M (0-100 µg/mL)
Incubation Time: 72 h
Result: Inhibited third-stage larvae and adult of N. americanus with IC50 values of 2.0 and 7.6 mg/mL, respectively.
In Vivo

Pyrantel pamoate (10 mg/kg; p.o.; single) reduces the worms in A. ceylanicum-infected hamsters, with the worm burden reduction of 87.2% and worm expulsion rate of 63.4%[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Syrian Golden hamsters (3-week-old; A. ceylanicum-infected)[2].
Dosage: 10 mg/kg
Administration: Oral administration; single.
Result: Exhibited worm burden reduction and worm expulsion rates of 87.2% and 63.4%, respectively.
Clinical Trial
Molecular Weight

594.68

Formula

C34H30N2O6S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=C(O)C(CC2=C3C=CC=CC3=CC(C(O)=O)=C2O)=C4C=CC=CC4=C1)O.CN5CCCN=C5/C=C/C6=CC=CS6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 20.83 mg/mL (35.03 mM; ultrasonic and warming and heat to 70°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6816 mL 8.4079 mL 16.8158 mL
5 mM 0.3363 mL 1.6816 mL 3.3632 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (4.20 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.94%

SDS (393 KB)

COA (256 KB) LCMS (102 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6816 mL 8.4079 mL 16.8158 mL 42.0394 mL
5 mM 0.3363 mL 1.6816 mL 3.3632 mL 8.4079 mL
10 mM 0.1682 mL 0.8408 mL 1.6816 mL 4.2039 mL
15 mM 0.1121 mL 0.5605 mL 1.1211 mL 2.8026 mL
20 mM 0.0841 mL 0.4204 mL 0.8408 mL 2.1020 mL
25 mM 0.0673 mL 0.3363 mL 0.6726 mL 1.6816 mL
30 mM 0.0561 mL 0.2803 mL 0.5605 mL 1.4013 mL
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Pyrantel pamoate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pyrantel22204-24-6Pyrantel embonateParasitenAChRAntibioticNicotinic acetylcholine receptorsparasitic infectionascariasishookwormpinwormtrichinosisInhibitorinhibitorinhibit

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