2. Immunology/Inflammation
  3. Interleukin Related
  4. Oxelumab

Oxelumab  (Synonyms: R 4930; huMAb OX 40L; Ro 49-89991)

Cat. No.: HY-P99408 Purity: ≥95.0%
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Oxelumab (R 4930) is a human monoclonal antibody against the OX40 ligand (OX40L). Oxelumab can be used for the research of asthma.

For research use only. We do not sell to patients.

CAS No. : 1186098-83-8

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Based on 1 publication(s) in Google Scholar

Oxelumab Related Antibodies

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Description

Oxelumab (R 4930) is a human monoclonal antibody against the OX40 ligand (OX40L). Oxelumab can be used for the research of asthma[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Human
In Vitro

Oxelumab (10 μg/mL; 3 d) represses cell proliferation of NK cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Oxelumab Related Antibodies

Cell Proliferation Assay[2]

Cell Line: Natural Killer (NK) cell lines
Concentration: 10 μg/mL
Incubation Time: 3 days
Result: Inhibited cell proliferation of NK cells.
In Vivo

Oxelumab (5 and 30 mg/kg; i.p., once daily for twice) affects the concentrations of IL-6 and the frequencies of splenic human effector memory T cells and switched B cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NSG mice with PBMCs from UC patients with simple clinical colitis activity index (SCCAI)[1]
Dosage: 5 and 30 mg/kg
Administration: Intraperitoneal injectionon; 5 and 30 mg/kg, once daily, on days 6 and 13
Result: Reversed the ethanol-induced colon dilated and the lost of distinct pattern of pellets. Decreased the level of IL-6 and increased the concentrations of glutamic acid. Reduced frequencies of splenic human effector memory T cells and switched B cells.
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Oxelumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation
References
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Oxelumab Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oxelumab1186098-83-8R 4930 huMAb OX 40L Ro 49-89991R4930R-4930Interleukin RelatedILAsthmaNKIL-6T cellB cellmiceInhibitorinhibitorinhibit

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