2. Membrane Transporter/Ion Channel Immunology/Inflammation
  3. P2X Receptor NOD-like Receptor (NLR)
  4. Oxidized ATP trisodium salt

Oxidized ATP trisodium salt  (Synonyms: oATP trisodium salt)

Cat. No.: HY-137888A Purity: ≥98.0%
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Oxidized ATP (oATP) trisodium salt is a broad-spectrum P2 receptor inhibitor. Oxidized ATP trisodium salt irreversibly antagonizes P2X7R activation. Oxidized ATP trisodium salt inhibits c-reactive protein (CRP)-induced NLRP3 inflammasome activation. Oxidized ATP trisodium salt can be used for research of atherosclerosis.

For research use only. We do not sell to patients.

Oxidized ATP trisodium salt Chemical Structure

Oxidized ATP trisodium salt Chemical Structure

CAS No. : 71997-40-5

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Based on 1 publication(s) in Google Scholar

Oxidized ATP trisodium salt Related Antibodies

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Description

Oxidized ATP (oATP) trisodium salt is a broad-spectrum P2 receptor inhibitor. Oxidized ATP trisodium salt irreversibly antagonizes P2X7R activation. Oxidized ATP trisodium salt inhibits c-reactive protein (CRP)-induced NLRP3 inflammasome activation. Oxidized ATP trisodium salt can be used for research of atherosclerosis[1][2].

IC50 & Target[1][2]

NLRP3 inflammasome

 

P2X7 Receptor

 

In Vitro

Oxidized ATP trisodium salt (100 μM, 1 h) inhibits CRP (20 μg/mL, 24 h)-induced caspase-1 activation and maturation of IL-1β in HUVECs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Oxidized ATP trisodium salt Related Antibodies
In Vivo

Oxidized ATP (300 μg/mouse, i.p., twice a week) trisodium salt ameliorates the induced mouse experimental autoimmune uveitis (EAU) in B6 mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Induced mouse experimental autoimmune uveitis (EAU)[2]
Dosage: 300 μg/mouse
Administration: i.p.
Result: Showed almost undetected EAU, as shown by fundoscopic and pathologic examination.
Decreased serum IL-17 level.
Mitigated the autoreactive T cell response.
Molecular Weight

571.11

Formula

C10H11N5Na3O13P3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=P(O)(O[Na])OP(OP(OC[C@H](C=O)O[C@@H](N1C2=NC=NC(N)=C2N=C1)C=O)(O[Na])=O)(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (87.55 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7510 mL 8.7549 mL 17.5098 mL
5 mM 0.3502 mL 1.7510 mL 3.5020 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (255 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.7510 mL 8.7549 mL 17.5098 mL 43.7744 mL
5 mM 0.3502 mL 1.7510 mL 3.5020 mL 8.7549 mL
10 mM 0.1751 mL 0.8755 mL 1.7510 mL 4.3774 mL
15 mM 0.1167 mL 0.5837 mL 1.1673 mL 2.9183 mL
20 mM 0.0875 mL 0.4377 mL 0.8755 mL 2.1887 mL
25 mM 0.0700 mL 0.3502 mL 0.7004 mL 1.7510 mL
30 mM 0.0584 mL 0.2918 mL 0.5837 mL 1.4591 mL
40 mM 0.0438 mL 0.2189 mL 0.4377 mL 1.0944 mL
50 mM 0.0350 mL 0.1751 mL 0.3502 mL 0.8755 mL
60 mM 0.0292 mL 0.1459 mL 0.2918 mL 0.7296 mL
80 mM 0.0219 mL 0.1094 mL 0.2189 mL 0.5472 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Oxidized ATP trisodium salt Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oxidized ATP trisodium71997-40-5oATP trisodiumP2X ReceptorNOD-like Receptor (NLR)P2XRsatherosclerosisCRPIL-1βHUVECsNLRP3 inflammasomeEAU modelInhibitorinhibitorinhibit

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