Oxprenolol (Synonyms: Ba 39089 free base)

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Oxprenolol (Ba 39089 free base) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a K_i of 7.10 nM in a radioligand binding assay using rat heart muscle.

For research use only. We do not sell to patients.

Oxprenolol Chemical Structure

CAS No. : 6452-71-7

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Other Forms of Oxprenolol:

Oxprenolol-d₇ Get quote
Oxprenolol hydrochloride Get quote

1 Publications Citing Use of MCE Oxprenolol

•J Pharmaceut Biomed. 2020, 113870.

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α adrenergic receptor β adrenergic receptor

Biological Activity
Purity & Documentation
References
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Description

Oxprenolol (Ba 39089 free base) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a K_i of 7.10 nM in a radioligand binding assay using rat heart muscle^[1].

IC₅₀ & Target^[1]

β-adrenoceptor

7.1 nM (Ki)

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	28.6 μM Compound: oxprenolol	Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy	[PMID: 18788725]

In Vitro

Oxprenolol is lipophilic^[3].
Oxprenolol shows permeability rate constant of 1.54 ± 1.54×10^-3 cm/h across abdominal human skin^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Oxprenolol (200 mg/kg/day; p.o.; daily for 3 weeks) produces effective beta-blockade together with peak plasma drug levels within the normal clinical range^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male rats (230 to 300 g body wt) of the Wistar strain^[2]
Dosage:	200 mg/kg
Administration:	Administered orally; daily for 3 weeks
Result:	This dosage produced effective beta-blockade.

Molecular Weight

265.35

Formula

C₁₅H₂₃NO₃

CAS No.

6452-71-7

SMILES

OC(COC1=CC=CC=C1OCC=C)CNC(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. T Nagatomo, et al. Binding Characteristics of ³H-dihydroalprenolol to Beta-Adrenoceptors of Rat Heart Treated With Neuraminidase. Jpn J Pharmacol. 1983 Aug;33(4):851-7. [Content Brief]

[2]. A S Manning, et al. Abrupt Withdrawal of Chronic Beta-Blockade: Adaptive Changes in Cyclic AMP and Contractility. J Mol Cell Cardiol. 1981 Nov;13(11):999-1009. [Content Brief]

[3]. Modamio P, et al. A comparative in vitro study of percutaneous penetration of β-blockers in human skin. International journal of pharmaceutics, 2000, 194(2): 249-259.

Oxprenolol Related Classifications

Cardiovascular Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oxprenolol6452-71-7Ba 39089Ba39089Ba-39089Adrenergic ReceptorBeta Receptorhypertensionlipophilicabdominal human skinInhibitorinhibitorinhibit

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