2. Apoptosis
  3. TNF Receptor
  4. Ozoralizumab

Ozoralizumab  (Synonyms: ATN-103)

Cat. No.: HY-P99796 Purity: 99.80%
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Ozoralizumab (ATN-103) is an anti-TNFα humanized antibody. Ozoralizumab is a humanized trivalent nanobody compound that consists of two anti-human TNFα nanobodies and an anti-human serum albumin (HSA) nanobody. Ozoralizumab can be used in research of arthritis.

For research use only. We do not sell to patients.

CAS No. : 1167985-17-2

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Based on 1 publication(s) in Google Scholar

Ozoralizumab Related Antibodies

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Description

Ozoralizumab (ATN-103) is an anti-TNFα humanized antibody. Ozoralizumab is a humanized trivalent nanobody compound that consists of two anti-human TNFα nanobodies and an anti-human serum albumin (HSA) nanobody. Ozoralizumab can be used in research of arthritis[1].

Isotype

VH-VH'-VH, trivalent
Species

Humanized
In Vitro

Ozoralizumab (ATN-103; 0-1000 pM; 48 h) has high TNFα-neutralizing potency in the L929 cell cytotoxicity assay with KD values of 20.2 pM and 16.1 pM for human TNFα and monkey TNFα, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ozoralizumab Related Antibodies
In Vivo

Ozoralizumab (ATN-103; 1 mg/kg; s.c.; Tg197 human TNF transgenic mice) inhibits arthritis and reduces arthritis scores[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Tg197 human TNF transgenic mice[1]
Dosage: 1 mg/kg
Administration: Subcutaneous injection
Result: Reduced the mean histopathologic score in the Tg197 mice.
Had ability to neutralize TNFα activity.
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Ozoralizumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • VH-VH'-VH, trivalent
Biological Activity
  • Immobilized Human TNF-alpha Protein (hFc Tag) can bind Ozoralizumab. The EC50 for this effect is 62.82 ng/mL.
Purity & Documentation
References
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Ozoralizumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ozoralizumab1167985-17-2ATN-103ATN103ATN 103TNF ReceptorTumor Necrosis Factor ReceptorTNFRserum albuminL929 cellarthritisInhibitorinhibitorinhibit

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