2. Membrane Transporter/Ion Channel Immunology/Inflammation
  3. P2X Receptor Interleukin Related
  4. P2X7-IN-2 TFA

P2X7-IN-2 TFA (compound 58) is a P2X7 receptor inhibitor. P2X7-IN-2 TFA inhibits IL-Iβ release with an IC50 value of 0.01 nM. P2X7-IN-2 TFA can be used for the research of autoimmunity, inflammation and cardiovascular disease.

For research use only. We do not sell to patients.

P2X7-IN-2 TFA Chemical Structure

P2X7-IN-2 TFA Chemical Structure

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1 mg USD 324 In-stock
5 mg USD 810 In-stock
10 mg USD 1300 In-stock
25 mg USD 2600 In-stock
50 mg USD 4200 In-stock
100 mg USD 7100 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of P2X7-IN-2 TFA:

P2X7-IN-2 TFA Related Antibodies

Top Publications Citing Use of Products

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

P2X7-IN-2 TFA (compound 58) is a P2X7 receptor inhibitor. P2X7-IN-2 TFA inhibits IL-Iβ release with an IC50 value of 0.01 nM. P2X7-IN-2 TFA can be used for the research of autoimmunity, inflammation and cardiovascular disease[1].

IC50 & Target

IC50: 0.01 nM (human whole blood IL-Iβ release)[1]
In Vitro

P2X7-IN-2 TFA (0-1 μM;30 min) inhibits human whole blood IL-Iβ release with an IC50 value of 0.01 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

P2X7-IN-2 TFA Related Antibodies
Molecular Weight

549.44

Formula

C24H22F7N3O4
Appearance

Solid

Color

Off-white to pink

SMILES

O=C(NC1=C(C)C=CC2=C1C=CN([C@H](C)CN)C2=O)CC3=CC=C(C(F)(F)F)C(F)=C3.O=C(O)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (182.00 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8200 mL 9.1002 mL 18.2003 mL
5 mM 0.3640 mL 1.8200 mL 3.6401 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.93%

COA (245 KB) HNMR (171 KB) LCMS (144 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8200 mL 9.1002 mL 18.2003 mL 45.5009 mL
5 mM 0.3640 mL 1.8200 mL 3.6401 mL 9.1002 mL
10 mM 0.1820 mL 0.9100 mL 1.8200 mL 4.5501 mL
15 mM 0.1213 mL 0.6067 mL 1.2134 mL 3.0334 mL
20 mM 0.0910 mL 0.4550 mL 0.9100 mL 2.2750 mL
25 mM 0.0728 mL 0.3640 mL 0.7280 mL 1.8200 mL
30 mM 0.0607 mL 0.3033 mL 0.6067 mL 1.5167 mL
40 mM 0.0455 mL 0.2275 mL 0.4550 mL 1.1375 mL
50 mM 0.0364 mL 0.1820 mL 0.3640 mL 0.9100 mL
60 mM 0.0303 mL 0.1517 mL 0.3033 mL 0.7583 mL
80 mM 0.0228 mL 0.1138 mL 0.2275 mL 0.5688 mL
100 mM 0.0182 mL 0.0910 mL 0.1820 mL 0.4550 mL
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P2X7-IN-2 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

P2X7-IN-2P2X ReceptorInterleukin RelatedP2XRsILisoquinolonecarboxamidepurinoceptorautoimmunityinflammationcardiovascularhuman whole bloodInhibitorinhibitorinhibit

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