Palmitoyl serotonin (Synonyms: PA-5HT)

Cat. No.: HY-131678 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Palmitoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin, antagonist of FAAH. Palmitoyl serotonin inhibits L-3,4-dihydroxyphenylalanine (HY-N0304) induced abnormal involuntary movements. Palmitoyl serotonin has the potential for the research of parkinson's disease (PD).

For research use only. We do not sell to patients.

Palmitoyl serotonin Chemical Structure

CAS No. : 212707-51-2

Size	Price	Stock	Quantity
1 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 775	Get quote	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Description

In Vivo

Palmitoyl serotonin (0.3 mg/kg; daily for 10 days) effectively attenuates the development of L-DOPA-induced dyskinesia (LID) and increases of ERK1/2 phosphorylation and FosB/ΔFosB expression in the hemi-parkinsonian mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	25-28 g, Eight-week-old male C57BL/6J mice ( 6-hydroxydopamine (6-OHDA)-induced hemiparkinsonian mouse model)^[1]
Dosage:	0.3 mg/kg
Administration:	daily for 10 days
Result:	Reduced axial, limb, and locomotive AIM scores on day 10, suppressed the hyper-phosphorylation of ERK1/2 in the 6-OHDA-lesioned striatum, suppressed the overexpression of FosB and ΔFosB in the 6-OHDA-lesioned striatum.

Molecular Weight

414.62

Formula

C₂₆H₄₂N₂O₂

CAS No.

212707-51-2

Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCCCCCC(NCCC1=CNC2=C1C=C(O)C=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMF : 30 mg/mL (72.36 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4118 mL	12.0592 mL	24.1185 mL
5 mM	0.4824 mL	2.4118 mL	4.8237 mL
10 mM	0.2412 mL	1.2059 mL	2.4118 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (267 KB) SDS (393 KB)

COA (240 KB)

Handling Instructions (2659 KB)

References

[1]. Park HY, et al. Palmitoyl Serotonin Inhibits L-dopa-induced Abnormal Involuntary Movements in the Mouse Parkinson Model. Exp Neurobiol. 2016 Aug;25(4):174-84.

[2]. Muthubharathi BC, et al. Physiological and Metabolite Alterations Associated with Neuronal Signals of Caenorhabditis elegans during Cronobacter sakazakii Infections. ACS Chem Neurosci. 2021 Nov 17;12(22):4336-4349. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMF	1 mM	2.4118 mL	12.0592 mL	24.1185 mL	60.2962 mL
	5 mM	0.4824 mL	2.4118 mL	4.8237 mL	12.0592 mL
	10 mM	0.2412 mL	1.2059 mL	2.4118 mL	6.0296 mL
	15 mM	0.1608 mL	0.8039 mL	1.6079 mL	4.0197 mL
	20 mM	0.1206 mL	0.6030 mL	1.2059 mL	3.0148 mL
	25 mM	0.0965 mL	0.4824 mL	0.9647 mL	2.4118 mL
	30 mM	0.0804 mL	0.4020 mL	0.8039 mL	2.0099 mL
	40 mM	0.0603 mL	0.3015 mL	0.6030 mL	1.5074 mL
	50 mM	0.0482 mL	0.2412 mL	0.4824 mL	1.2059 mL
	60 mM	0.0402 mL	0.2010 mL	0.4020 mL	1.0049 mL

Palmitoyl serotonin Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Palmitoyl serotonin212707-51-2PA-5HTOthersdyskinesiaERK1/2 phosphorylationFosB/ΔFosBparkinson's diseaseInhibitorinhibitorinhibit

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