2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. PARP Apoptosis
  4. PARP10/15-IN-2

PARP10/15-IN-2 (Compound 8h) is a potent PARP10 and PARP15 dual inhibitor with IC50 values of 0.15 µM and 0.37 µM against PARP10 and PARP15, respectively. PARP10/15-IN-2 is able to enter cells and rescue cells from apoptosis.

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PARP10/15-IN-2 Chemical Structure

PARP10/15-IN-2 Chemical Structure

CAS No. : 2892064-99-0

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Based on 1 publication(s) in Google Scholar

PARP10/15-IN-2 Related Antibodies

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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  • Purity & Documentation

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Description

PARP10/15-IN-2 (Compound 8h) is a potent PARP10 and PARP15 dual inhibitor with IC50 values of 0.15 µM and 0.37 µM against PARP10 and PARP15, respectively. PARP10/15-IN-2 is able to enter cells and rescue cells from apoptosis[1].

IC50 & Target

PARP10

0.15 μM (IC50)

PARP15

0.37 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
HeLa EC50
1.6 μM
Compound: 8h
Rescue of cell viability in human HeLa cells expressing wild type PARP10 at upto 10 uM incubated for 10 to 12 days by methylene blue dye based colony formation assay
Rescue of cell viability in human HeLa cells expressing wild type PARP10 at upto 10 uM incubated for 10 to 12 days by methylene blue dye based colony formation assay
[PMID: 35500474]
Molecular Weight

286.26

Formula

C15H11FN2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1NNC(C2=C1C=CC(OCC3=CC=CC=C3F)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (174.67 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4933 mL 17.4666 mL 34.9333 mL
5 mM 0.6987 mL 3.4933 mL 6.9867 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4933 mL 17.4666 mL 34.9333 mL 87.3332 mL
5 mM 0.6987 mL 3.4933 mL 6.9867 mL 17.4666 mL
10 mM 0.3493 mL 1.7467 mL 3.4933 mL 8.7333 mL
15 mM 0.2329 mL 1.1644 mL 2.3289 mL 5.8222 mL
20 mM 0.1747 mL 0.8733 mL 1.7467 mL 4.3667 mL
25 mM 0.1397 mL 0.6987 mL 1.3973 mL 3.4933 mL
30 mM 0.1164 mL 0.5822 mL 1.1644 mL 2.9111 mL
40 mM 0.0873 mL 0.4367 mL 0.8733 mL 2.1833 mL
50 mM 0.0699 mL 0.3493 mL 0.6987 mL 1.7467 mL
60 mM 0.0582 mL 0.2911 mL 0.5822 mL 1.4556 mL
80 mM 0.0437 mL 0.2183 mL 0.4367 mL 1.0917 mL
100 mM 0.0349 mL 0.1747 mL 0.3493 mL 0.8733 mL
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PARP10/15-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PARP10/15-IN-22892064-99-0PARPApoptosispoly ADP ribose polymerase HeLaanticancerADP-RibosyltransferasesInhibitorinhibitorinhibit

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