2. Antibody-drug Conjugate/ADC Related
  3. Antibody-Drug Conjugates (ADCs)
  4. Patritumab deruxtecan

Patritumab deruxtecan  (Synonyms: HER3-DXd; U3-1402)

Cat. No.: HY-P99813 Purity: 99.08%
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Patritumab deruxtecan (HER3-DXd) is an antibody-drug conjugate (ADC) consisting of a fully human anti-HER3 IgG1 monoclonal antibody Patritumab (HY-P99275) attached to a topoisomerase I inhibitor payload via a tetrapeptide-based cleavable linker. Patritumab deruxtecan shows anticancer activity.

For research use only. We do not sell to patients.

Patritumab deruxtecan Chemical Structure

Patritumab deruxtecan Chemical Structure

CAS No. : 2227102-46-5

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Based on 1 publication(s) in Google Scholar

Patritumab deruxtecan Related Antibodies

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Description

Patritumab deruxtecan (HER3-DXd) is an antibody-drug conjugate (ADC) consisting of a fully human anti-HER3 IgG1 monoclonal antibody Patritumab (HY-P99275) attached to a topoisomerase I inhibitor payload via a tetrapeptide-based cleavable linker. Patritumab deruxtecan shows anticancer activity[1].

In Vitro

Patritumab deruxtecan exhibits activity against breast cancer cells expressing HER3 mutations with and without HER2 overexpression[1].
Patritumab deruxtecan (0-100 nM) binds to the surface of all HER3-mutant and HER3WT MDA-MB-231 cells in a concentration-dependent manner, but does not bind to the surface of HER3EV cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Patritumab deruxtecan Related Antibodies
Clinical Trial
Molecular Weight

158000 (average)

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Patritumab deruxtecan]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Patritumab deruxtecan Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Patritumab deruxtecan2227102-46-5HER3-DXd U3-1402Antibody-Drug Conjugates (ADCs)Antibody-Drug Conjugatesbreast cancerMDA-MB-231 cellsInhibitorinhibitorinhibit

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