2. Anti-infection
  3. Bacterial
  4. PC190723

PC190723 is a bacterial cell division protein FtsZ inhibitor with an IC50 of 55 ng/mL. PC190723 has bactericidal activity against B. subtilis and a variety of staphylococci, with MIC ranging from 0.5 and 1.0 μg/mL. PC190723 exerts antibacterial activity by enhancing FtsZ polymer assembly and inhibiting depolymerization.

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PC190723 Chemical Structure

PC190723 Chemical Structure

CAS No. : 951120-33-5

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Based on 1 publication(s) in Google Scholar

PC190723 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

PC190723 is a bacterial cell division protein FtsZ inhibitor with an IC50 of 55 ng/mL. PC190723 has bactericidal activity against B. subtilis and a variety of staphylococci, with MIC ranging from 0.5 and 1.0 μg/mL. PC190723 exerts antibacterial activity by enhancing FtsZ polymer assembly and inhibiting depolymerization[1][2][3].

IC50 & Target

IC50: 55 ng/mL (FtsZ)[1]
Cellular Effect
Cell Line Type Value Description References
L929 IC50
> 100 μM
Compound: 1; PC190723
Cytotoxicity against mouse L929 cells by MTS assay
Cytotoxicity against mouse L929 cells by MTS assay
[PMID: 30503946]
In Vitro

PC190723 (0.001-10 μg/mL) directly inhibits the GTPase activity of FtsZ in a concentration-dependent manner, with an IC50 of 55 ng/mL[1].
PC190723 (2 μg/mL; 2 hours) causes the elongation or enlargement of rod-shaped B. subtilis and spherical S. aureus and reduces cell viability[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PC190723 Related Antibodies
In Vivo

PC190723 (30 mg/kg; subcutaneous/intravenous injection; single dose) has antibacterial effect in a mouse model of S. aureus infection[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: S. aureus treated mice[1]
Dosage: 30 mg/kg
Administration: Subcutaneous/intravenous injection; Single dose
Result: Resulted in a 100% survival of mice inoculated intraperitoneally with a potentially lethal dose of S. aureus, as compared with a 0% survival for the group receiving no compound.
Produced dose-dependent efficacy for both routes of administration with ED50 were 7.3 and 10.2 mg/kg for S.C. and I.V. administration, respectively.
Molecular Weight

355.75

Formula

C14H8ClF2N3O2S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

NC(C1=C(C(OCC2=NC3=C(S2)N=CC(Cl)=C3)=CC=C1F)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (562.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8110 mL 14.0548 mL 28.1096 mL
5 mM 0.5622 mL 2.8110 mL 5.6219 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 5 mg/mL (14.05 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 5 mg/mL (14.05 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8110 mL 14.0548 mL 28.1096 mL 70.2741 mL
5 mM 0.5622 mL 2.8110 mL 5.6219 mL 14.0548 mL
10 mM 0.2811 mL 1.4055 mL 2.8110 mL 7.0274 mL
15 mM 0.1874 mL 0.9370 mL 1.8740 mL 4.6849 mL
20 mM 0.1405 mL 0.7027 mL 1.4055 mL 3.5137 mL
25 mM 0.1124 mL 0.5622 mL 1.1244 mL 2.8110 mL
30 mM 0.0937 mL 0.4685 mL 0.9370 mL 2.3425 mL
40 mM 0.0703 mL 0.3514 mL 0.7027 mL 1.7569 mL
50 mM 0.0562 mL 0.2811 mL 0.5622 mL 1.4055 mL
60 mM 0.0468 mL 0.2342 mL 0.4685 mL 1.1712 mL
80 mM 0.0351 mL 0.1757 mL 0.3514 mL 0.8784 mL
100 mM 0.0281 mL 0.1405 mL 0.2811 mL 0.7027 mL
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PC190723 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PC190723951120-33-5PC 190723PC-190723BacterialS. aureus infection modelB. subtilisstaphylococciInhibitorinhibitorinhibit

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