2. Metabolic Enzyme/Protease Autophagy Anti-infection
  3. Phosphodiesterase (PDE) Autophagy HIV
  4. Pentoxifylline-d6

Pentoxifylline-d6  (Synonyms: BL-191-d6; PTX-d6; Oxpentifylline-d6)

Cat. No.: HY-B0715S Purity: ≥99.0%
COA Handling Instructions

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Pentoxifylline-d6 is the deuterium labeled Pentoxifylline. Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation[1][2][3].

For research use only. We do not sell to patients.

Pentoxifylline-d<sub>6</sub> Chemical Structure

Pentoxifylline-d6 Chemical Structure

CAS No. : 1185878-98-1

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1 mg USD 340 In-stock
5 mg USD 850 In-stock
10 mg USD 1360 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Pentoxifylline-d6:

Pentoxifylline-d6 Related Antibodies

Top Publications Citing Use of Products

View All Phosphodiesterase (PDE) Isoform Specific Products:

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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HIV HIV-1 HIV-2

  • Biological Activity

  • Purity & Documentation

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Description

Pentoxifylline-d6 is the deuterium labeled Pentoxifylline. Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pentoxifylline-d6 Related Antibodies
Molecular Weight

284.34

Formula

C13H12D6N4O3
CAS No.
Unlabeled CAS

6493-05-6
Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=C(N(C([2H])([2H])[2H])C(=O)N1CCCCC(C)=O)N=CN2C([2H])([2H])[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 10 mg/mL (35.17 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : ≥ 10 mg/mL (35.17 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : ≥ 10 mg/mL (35.17 mM)

DMF : ≥ 10 mg/mL (35.17 mM)

Ethanol : ≥ 2 mg/mL (7.03 mM)

Ethanol : ≥ 2 mg/mL (7.03 mM)

PBS (pH 7.2) : ≥ 1 mg/mL (3.52 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5169 mL 17.5846 mL 35.1692 mL
5 mM 0.7034 mL 3.5169 mL 7.0338 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
PBS (pH 7.2) / Ethanol / Ethanol / DMSO / DMSO / DMF / DMF 1 mM 3.5169 mL 17.5846 mL 35.1692 mL 87.9229 mL
Ethanol / Ethanol / DMSO / DMSO / DMF / DMF 5 mM 0.7034 mL 3.5169 mL 7.0338 mL 17.5846 mL
DMSO / DMSO / DMF / DMF 10 mM 0.3517 mL 1.7585 mL 3.5169 mL 8.7923 mL
15 mM 0.2345 mL 1.1723 mL 2.3446 mL 5.8615 mL
20 mM 0.1758 mL 0.8792 mL 1.7585 mL 4.3961 mL
25 mM 0.1407 mL 0.7034 mL 1.4068 mL 3.5169 mL
30 mM 0.1172 mL 0.5862 mL 1.1723 mL 2.9308 mL
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Pentoxifylline-d6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pentoxifylline-d61185878-98-1BL-191-d6PTX-d6Oxpentifylline-d6Phosphodiesterase (PDE)AutophagyHIVHuman immunodeficiency virusInhibitorinhibitorinhibit

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