2. Cell Cycle/DNA Damage
  3. PERK
  4. PERK-IN-6

PERK-IN-6 (Compound 5) is a PERK inhibitor with an IC50 of 2.5 nM.

For research use only. We do not sell to patients.

PERK-IN-6 Chemical Structure

PERK-IN-6 Chemical Structure

CAS No. : 1337532-14-5

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Based on 1 publication(s) in Google Scholar

PERK-IN-6 Related Antibodies

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Description

PERK-IN-6 (Compound 5) is a PERK inhibitor with an IC50 of 2.5 nM[1].

IC50 & Target

IC50: 2.5 nM (PERK)[1]
Cellular Effect
Cell Line Type Value Description References
A549 IC50
0.1 μM
Compound: 5
Inhibition of thapsigargin-induced autophosphorylation of PERK in human A549 cells preincubated for 1 hr followed by thapsigargin-induction measured after 1 hr by Western blotting analysis
Inhibition of thapsigargin-induced autophosphorylation of PERK in human A549 cells preincubated for 1 hr followed by thapsigargin-induction measured after 1 hr by Western blotting analysis
[PMID: 24900593]
In Vitro

PERK-IN-6 (Compound 5) inhibits thapsigargin induced PERK autophosphorylation with an IC50 of 0.1-0.3 μΜ in A549 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PERK-IN-6 Related Antibodies
In Vivo

The rat blood clearance of PERK-IN-6 (Compound 5) is 10.5 mL/min/kg after i.v infusion in SD rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

398.46

Formula

C23H22N6O
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(CC1=NC(C)=CC=C1)N2C3=C(CC2)C=C(C4=CN(C)C5=C4C(N)=NC=N5)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (31.37 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5097 mL 12.5483 mL 25.0966 mL
5 mM 0.5019 mL 2.5097 mL 5.0193 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5097 mL 12.5483 mL 25.0966 mL 62.7416 mL
5 mM 0.5019 mL 2.5097 mL 5.0193 mL 12.5483 mL
10 mM 0.2510 mL 1.2548 mL 2.5097 mL 6.2742 mL
15 mM 0.1673 mL 0.8366 mL 1.6731 mL 4.1828 mL
20 mM 0.1255 mL 0.6274 mL 1.2548 mL 3.1371 mL
25 mM 0.1004 mL 0.5019 mL 1.0039 mL 2.5097 mL
30 mM 0.0837 mL 0.4183 mL 0.8366 mL 2.0914 mL
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PERK-IN-6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PERK-IN-61337532-14-5PERKProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinaseInhibitorinhibitorinhibit

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