2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Petosemtamab

Petosemtamab  (Synonyms: MCLA 158)

Cat. No.: HY-P99406 Purity: 95.00%
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Petosemtamab (MCLA 158) is an anti- EGFR (Kd: 0.22 nM) and anti-LGR5 (Kd: 0.86 nM) monoclonal antibody (mAb). Petosemtamab leads to EGFR signaling blockade and receptor degradation in LGR5+ cancer cells. Petosemtamab can be used in the research of solid tumors, such as head and neck squamous cell carcinoma (HNSCC), metastatic colorectal cancer (CRC).

For research use only. We do not sell to patients.

CAS No. : 2213450-26-9

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1 mg USD 430 In-stock
5 mg USD 1120 In-stock
10 mg USD 1800 In-stock
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Based on 1 publication(s) in Google Scholar

Petosemtamab Related Antibodies

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Description

Petosemtamab (MCLA 158) is an anti- EGFR (Kd: 0.22 nM) and anti-LGR5 (Kd: 0.86 nM) monoclonal antibody (mAb). Petosemtamab leads to EGFR signaling blockade and receptor degradation in LGR5+ cancer cells. Petosemtamab can be used in the research of solid tumors, such as head and neck squamous cell carcinoma (HNSCC), metastatic colorectal cancer (CRC)[1][2].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Bispecific

IC50 & Target[2]

EGFR

0.22 nM (Kd)

LGR5

0.85 nM (Kd)

In Vitro

MCLA-158 (1 µg/mL, 24 or 72 h) leads to EGFR degradation in EGFR+/LGR5+ colorectal cancer organoids[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Petosemtamab Related Antibodies

Western Blot Analysis[2]

Cell Line: P18T (KRAS WT), C55T (KRAS G12V) and C82N (normal) organoids
Concentration: 1 µg/mL
Incubation Time: 1, 6, 24, 72 h
Result: Time-dependently degraded EGFR.
In Vivo

MCLA-158 (25 mg/kg/week, i.v., for 6 weeks) leads to tumor regression in esophageal squamous, gastric adenocarcinoma and head & neck PDX models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Esophageal squamous, gastric adenocarcinoma and head & neck PDX models[2]
Dosage: 25 mg/kg/week
Administration: Intravenous injection (i.v.) for 6 weeks.
Result: Inhibited tumor growth.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Petosemtamab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized EGFR Protein, Human can bind Petosemtamab. The EC50 for this effect is 1.904 ng/mL.
Purity & Documentation

Purity: 95.00%

SDS (251 KB)

COA (231 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Petosemtamab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Petosemtamab2213450-26-9MCLA 158MCLA158MCLA-158EGFREpidermal growth factor receptorErbB-1HER1CRCcolorectal cancerHNSCChead and neck squamous cell carcinomaEGFR degradationInhibitorinhibitorinhibit

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