2. PI3K/Akt/mTOR NF-κB
  3. Akt NF-κB
  4. Phellodendrine

Phellodendrine, a isoquinoline alkaloid, is one of important characteristic ingredients in the Phellodendron amurense. phellodendrine is against AAPH-induced oxidative stress through regulating the AKT/NF-κB pathway. Phellodendrine has good antioxidant, and anti-inflammatory effect .

For research use only. We do not sell to patients.

Phellodendrine Chemical Structure

Phellodendrine Chemical Structure

CAS No. : 6873-13-8

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Based on 1 publication(s) in Google Scholar

Other Forms of Phellodendrine:

Phellodendrine Related Antibodies

Top Publications Citing Use of Products

View All Akt Isoform Specific Products:

View All Isoforms
Akt Akt1 Akt2 Akt3

View All NF-κB Isoform Specific Products:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

Phellodendrine, a isoquinoline alkaloid, is one of important characteristic ingredients in the Phellodendron amurense. phellodendrine is against AAPH-induced oxidative stress through regulating the AKT/NF-κB pathway. Phellodendrine has good antioxidant, and anti-inflammatory effect [1].

IC50 & Target[1]

NF-κB

 

Molecular Weight

342.41

Formula

C20H24NO4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

OC1=C(OC)C=C2CC[N@@+]3(C)CC4=CC(OC)=C(O)C=C4C[C@@]3([H])C2=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (14.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9205 mL 14.6024 mL 29.2048 mL
5 mM 0.5841 mL 2.9205 mL 5.8410 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9205 mL 14.6024 mL 29.2048 mL 73.0119 mL
5 mM 0.5841 mL 2.9205 mL 5.8410 mL 14.6024 mL
10 mM 0.2920 mL 1.4602 mL 2.9205 mL 7.3012 mL
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Phellodendrine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phellodendrine6873-13-8AktNF-κBPKBProtein kinase BNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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