Phenserine tartrate  (Synonyms: (-)-Eseroline phenylcarbamate tartrate; (-)-Phenserine (+)-tartrate)

Phenserine tartrate ((-)-Eseroline phenylcarbamate) is a derivative of Physostigmine and is a potent, noncompetitive, long-acting and selective AChE inhibitor. Phenserine tartrate reduces β-amyloid precursor protein (APP) and β-amyloid peptide (Aβ) formation. Phenserine tartrate improves cognitive performance and attenuates the progression of Alzheimer's disease^[1][2][3].

AChE; β-amyloid precursor protein; β-amyloid peptide^[1]

Phenserine (1-25 μM; 48 hours; CHO APP_751SW cells) treatment CHO APP_751SW cell shows 18.6% reduction in cells treated with 10 μM of Phenserine, while 25 μM concentration of Phenserine reduces APP level by 51.4%^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Phenserine (1-4 mg/kg; intraperitoneal injection; for 4 days; male Fischer-344 rats) treatment improves learning when cholinergic function has been impaired in a spatial memory task^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

487.50

C₂₄H₂₉N₃O₈

156910-61-1

OC([C@H](O)[C@@H](O)C(O)=O)=O.C[C@]12C3=CC(OC(NC4=CC=CC=C4)=O)=CC=C3N([C@@]1([H])N(CC2)C)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Klein J. Phenserine. Expert Opin Investig Drugs. 2007 Jul;16(7):1087-97.  [Content Brief]

  [2]. Asuni AA, et al. Modulation of amyloid precursor protein expression reduces β-amyloid deposition in a mouse model. Ann Neurol. 2014 May;75(5):684-99.  [Content Brief]

  [3]. https://www.ncbi.nlm.nih.gov/pubmed/24687915  [Content Brief]