1. Immunology/Inflammation
  2. COX
  3. Phenylbutazone-13C12

Phenylbutazone-13C12 is the 13C12 labeled Phenylbutazone. Phenylbutazone is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS). Phenylbutazone, a hepatotoxin, is a nonsteroidal anti-inflammatory agent (NSAID). Phenylbutazone induces muscle blind-like protein 1 (MBNL1) expression and has the potential for ankylosing spondylitis research.

For research use only. We do not sell to patients.

Phenylbutazone-<sup>13</sup>C<sub>12</sub> Chemical Structure

Phenylbutazone-13C12 Chemical Structure

CAS No. : 1325559-13-4

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1 mg USD 190 In-stock
5 mg USD 570 In-stock
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50 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Phenylbutazone-13C12 is the 13C12 labeled Phenylbutazone. Phenylbutazone is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS). Phenylbutazone, a hepatotoxin, is a nonsteroidal anti-inflammatory agent (NSAID). Phenylbutazone induces muscle blind-like protein 1 (MBNL1) expression and has the potential for ankylosing spondylitis research.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

320.29

Formula

C713C12H20N2O2

CAS No.
Unlabeled CAS

50-33-9

Appearance

Solid

Color

White to off-white

SMILES

O=C1N([13C]2=[13CH][13CH]=[13CH][13CH]=[13CH]2)N([13C]3=[13CH][13CH]=[13CH][13CH]=[13CH]3)C(C1CCCC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (312.22 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : ≥ 100 mg/mL (312.22 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 0.67 mg/mL (2.09 mM; Need ultrasonic)

H2O : 0.67 mg/mL (2.09 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1222 mL 15.6109 mL 31.2217 mL
5 mM 0.6244 mL 3.1222 mL 6.2443 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / H2O / DMSO / DMSO 1 mM 3.1222 mL 15.6109 mL 31.2217 mL 78.0543 mL
DMSO / DMSO 5 mM 0.6244 mL 3.1222 mL 6.2443 mL 15.6109 mL
10 mM 0.3122 mL 1.5611 mL 3.1222 mL 7.8054 mL
15 mM 0.2081 mL 1.0407 mL 2.0814 mL 5.2036 mL
20 mM 0.1561 mL 0.7805 mL 1.5611 mL 3.9027 mL
25 mM 0.1249 mL 0.6244 mL 1.2489 mL 3.1222 mL
30 mM 0.1041 mL 0.5204 mL 1.0407 mL 2.6018 mL
40 mM 0.0781 mL 0.3903 mL 0.7805 mL 1.9514 mL
50 mM 0.0624 mL 0.3122 mL 0.6244 mL 1.5611 mL
60 mM 0.0520 mL 0.2602 mL 0.5204 mL 1.3009 mL
80 mM 0.0390 mL 0.1951 mL 0.3903 mL 0.9757 mL
100 mM 0.0312 mL 0.1561 mL 0.3122 mL 0.7805 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Phenylbutazone-13C12
Cat. No.:
HY-B0230S2
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