Phenylbutazone-¹³C₁₂

Name: Phenylbutazone- 13 C 12
Brand: MedChemExpress
SKU: HY-B0230S2
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0230S2 Purity: 99.90%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Phenylbutazone-¹³C₁₂ is the ¹³C₁₂ labeled Phenylbutazone. Phenylbutazone is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS). Phenylbutazone, a hepatotoxin, is a nonsteroidal anti-inflammatory agent (NSAID). Phenylbutazone induces muscle blind-like protein 1 (MBNL1) expression and has the potential for ankylosing spondylitis research.

For research use only. We do not sell to patients.

Phenylbutazone-<sup>13</sup>C<sub>12</sub> Chemical Structure

Phenylbutazone-¹³C₁₂ Chemical Structure

CAS No. : 1325559-13-4

Size	Price	Stock	Quantity
1 mg	USD 190	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 570	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Phenylbutazone-¹³C₁₂:

Phenylbutazone In-stock

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COX COX-1 COX-2 COX-3

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

320.29

Formula

C₇¹³C₁₂H₂₀N₂O₂

CAS No.

1325559-13-4

Unlabeled CAS

50-33-9

Appearance

Solid

Color

White to off-white

SMILES

O=C1N([13C]2=[13CH][13CH]=[13CH][13CH]=[13CH]2)N([13C]3=[13CH][13CH]=[13CH][13CH]=[13CH]3)C(C1CCCC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (312.22 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 0.67 mg/mL (2.09 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1222 mL	15.6109 mL	31.2217 mL
5 mM	0.6244 mL	3.1222 mL	6.2443 mL
10 mM	0.3122 mL	1.5611 mL	3.1222 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.90%

Select Batch:

Data Sheet (282 KB) SDS (252 KB)

COA (261 KB) RP-HPLC (87 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

[2]. G A Reed, et al. Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone. Requirement for peroxidative metabolism. Mol Pharmacol. 1985 Jan;27(1):109-14. [Content Brief]

[3]. Guiying Chen, et al. Phenylbutazone induces expression of MBNL1 and suppresses formation of MBNL1-CUG RNA foci in a mouse model of myotonic dystrophy. Sci Rep. 2016 Apr 29;6:25317. [Content Brief]

[4]. Beretta C, et al. COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis. Pharmacol Res. 2005 Oct;52(4):302-6. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / H₂O / DMSO / DMSO	1 mM	3.1222 mL	15.6109 mL	31.2217 mL	78.0543 mL
DMSO / DMSO	5 mM	0.6244 mL	3.1222 mL	6.2443 mL	15.6109 mL
	10 mM	0.3122 mL	1.5611 mL	3.1222 mL	7.8054 mL
	15 mM	0.2081 mL	1.0407 mL	2.0814 mL	5.2036 mL
	20 mM	0.1561 mL	0.7805 mL	1.5611 mL	3.9027 mL
	25 mM	0.1249 mL	0.6244 mL	1.2489 mL	3.1222 mL
	30 mM	0.1041 mL	0.5204 mL	1.0407 mL	2.6018 mL
	40 mM	0.0781 mL	0.3903 mL	0.7805 mL	1.9514 mL
	50 mM	0.0624 mL	0.3122 mL	0.6244 mL	1.5611 mL
	60 mM	0.0520 mL	0.2602 mL	0.5204 mL	1.3009 mL
	80 mM	0.0390 mL	0.1951 mL	0.3903 mL	0.9757 mL
	100 mM	0.0312 mL	0.1561 mL	0.3122 mL	0.7805 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.