Phenylbutazone(diphenyl-d₁₀)

Name: Phenylbutazone(diphenyl-d 10 )
Brand: MedChemExpress
SKU: HY-B0230S
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0230S Purity: 98.70%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Phenylbutazone(diphenyl-d₁₀) is the deuterium labeled Phenylbutazone. Phenylbutazone is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS). Phenylbutazone, a hepatotoxin, is a nonsteroidal anti-inflammatory agent (NSAID). Phenylbutazone induces muscle blind-like protein 1 (MBNL1) expression and has the potential for ankylosing spondylitis research[1][2].

For research use only. We do not sell to patients.

Phenylbutazone(diphenyl-d<sub>10</sub>) Chemical Structure

Phenylbutazone(diphenyl-d₁₀) Chemical Structure

CAS No. : 1219794-69-0

Size	Price	Stock	Quantity
1 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 800	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Phenylbutazone(diphenyl-d₁₀):

Phenylbutazone In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

318.44

Formula

C₁₉H₁₀D₁₀N₂O₂

CAS No.

1219794-69-0

Unlabeled CAS

50-33-9

Appearance

Solid

Color

White to off-white

SMILES

O=C1N(N(C(=O)C1CCCC)C2=C(C(=C(C(=C2[2H])[2H])[2H])[2H])[2H])C3=C(C(=C(C(=C3[2H])[2H])[2H])[2H])[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (314.03 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 0.67 mg/mL (2.10 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1403 mL	15.7015 mL	31.4031 mL
5 mM	0.6281 mL	3.1403 mL	6.2806 mL
10 mM	0.3140 mL	1.5702 mL	3.1403 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.70%

Select Batch:

Data Sheet (279 KB) SDS (251 KB)

COA (257 KB) RP-HPLC (310 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. G A Reed, et al. Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone. Requirement for peroxidative metabolism. Mol Pharmacol. 1985 Jan;27(1):109-14. [Content Brief]

[3]. Guiying Chen, et al. Phenylbutazone induces expression of MBNL1 and suppresses formation of MBNL1-CUG RNA foci in a mouse model of myotonic dystrophy. Sci Rep. 2016 Apr 29;6:25317. [Content Brief]

[4]. Beretta C, et al. COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis. Pharmacol Res. 2005 Oct;52(4):302-6. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / H₂O / DMSO / DMSO	1 mM	3.1403 mL	15.7015 mL	31.4031 mL	78.5077 mL
DMSO / DMSO	5 mM	0.6281 mL	3.1403 mL	6.2806 mL	15.7015 mL
	10 mM	0.3140 mL	1.5702 mL	3.1403 mL	7.8508 mL
	15 mM	0.2094 mL	1.0468 mL	2.0935 mL	5.2338 mL
	20 mM	0.1570 mL	0.7851 mL	1.5702 mL	3.9254 mL
	25 mM	0.1256 mL	0.6281 mL	1.2561 mL	3.1403 mL
	30 mM	0.1047 mL	0.5234 mL	1.0468 mL	2.6169 mL
	40 mM	0.0785 mL	0.3925 mL	0.7851 mL	1.9627 mL
	50 mM	0.0628 mL	0.3140 mL	0.6281 mL	1.5702 mL
	60 mM	0.0523 mL	0.2617 mL	0.5234 mL	1.3085 mL
	80 mM	0.0393 mL	0.1963 mL	0.3925 mL	0.9813 mL
	100 mM	0.0314 mL	0.1570 mL	0.3140 mL	0.7851 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.