2. PI3K/Akt/mTOR
  3. mTOR PI3K
  4. PI3K-IN-18

PI3K-IN-18 (Compound 1) is a PI3K inhibitor, and can also effectively inhibit the homologous enzymemTOR. The IC50 values of PI3K-IN-18 for mTOR and PI3K-α were 49 nM and 41 nM, respectively.

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PI3K-IN-18 Chemical Structure

PI3K-IN-18 Chemical Structure

CAS No. : 371943-05-4

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Based on 1 publication(s) in Google Scholar

Other Forms of PI3K-IN-18:

PI3K-IN-18 Related Antibodies

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Description

PI3K-IN-18 (Compound 1) is a PI3K inhibitor, and can also effectively inhibit the homologous enzymemTOR. The IC50 values of PI3K-IN-18 for mTOR and PI3K-α were 49 nM and 41 nM, respectively[1].

IC50 & Target

mTOR

49 nM (IC50)

PI3Kα

41 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
A2780 IC50
0.27 μM
Compound: 1
Antiproliferative activity against human A2780 cells with PIK3CA and PTEN mutation after 4 days by alamar blue assay
Antiproliferative activity against human A2780 cells with PIK3CA and PTEN mutation after 4 days by alamar blue assay
[PMID: 18754654]
Sf9 IC50
0.008 μM
Compound: 1
Inhibition of human recombinant PI3K p110alpha expressed in Sf9 cells coexpressing p85alpha by radiometric scintillation proximity assay
Inhibition of human recombinant PI3K p110alpha expressed in Sf9 cells coexpressing p85alpha by radiometric scintillation proximity assay
[PMID: 18754654]
U-87MG ATCC IC50
1.1 μM
Compound: 1
Antiproliferative activity against PTEN-null human U87MG cells after 4 days by alamar blue assay
Antiproliferative activity against PTEN-null human U87MG cells after 4 days by alamar blue assay
[PMID: 18754654]
Molecular Weight

313.37

Formula

C16H15N3O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC(C2=NC3=C(C(N4CCOCC4)=N2)SC=C3)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (79.78 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1911 mL 15.9556 mL 31.9112 mL
5 mM 0.6382 mL 3.1911 mL 6.3822 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

SDS (251 KB)

COA (252 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1911 mL 15.9556 mL 31.9112 mL 79.7779 mL
5 mM 0.6382 mL 3.1911 mL 6.3822 mL 15.9556 mL
10 mM 0.3191 mL 1.5956 mL 3.1911 mL 7.9778 mL
15 mM 0.2127 mL 1.0637 mL 2.1274 mL 5.3185 mL
20 mM 0.1596 mL 0.7978 mL 1.5956 mL 3.9889 mL
25 mM 0.1276 mL 0.6382 mL 1.2764 mL 3.1911 mL
30 mM 0.1064 mL 0.5319 mL 1.0637 mL 2.6593 mL
40 mM 0.0798 mL 0.3989 mL 0.7978 mL 1.9944 mL
50 mM 0.0638 mL 0.3191 mL 0.6382 mL 1.5956 mL
60 mM 0.0532 mL 0.2659 mL 0.5319 mL 1.3296 mL
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PI3K-IN-18 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K-IN-18371943-05-4mTORPI3KMammalian target of RapamycinPhosphoinositide 3-kinasemTOR inhibitorsOncologyKinaseInhibitorinhibitorinhibit

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