PI3K-IN-18 dihydrochloride

Cat. No.: HY-109633A Purity: 99.70%: FAQs
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PI3K-IN-18 (Compound 1) dihydrochloride is a 4-morpholino-2-phenylquinazoline derivative and an inhibitor of PI3K p110α.

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PI3K-IN-18 dihydrochloride Chemical Structure

CAS No. : 1188890-32-5

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of PI3K-IN-18 dihydrochloride:

PI3K-IN-18 Get quote

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•Related Small Molecules:

•Related Proteins:

View All PI3K Isoform Specific Products:

View All Isoforms

PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

Biological Activity
Purity & Documentation
References
Customer Review

Description

PI3K-IN-18 (Compound 1) dihydrochloride is a 4-morpholino-2-phenylquinazoline derivative and an inhibitor of PI3K p110α^[1].

Molecular Weight

386.30

Formula

C₁₆H₁₇Cl₂N₃O₂S

CAS No.

1188890-32-5

Appearance

Solid

Color

White to off-white

SMILES

OC1=CC(C2=NC(N3CCOCC3)=C4SC=CC4=N2)=CC=C1.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 10 mg/mL (25.89 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5887 mL	12.9433 mL	25.8866 mL
5 mM	0.5177 mL	2.5887 mL	5.1773 mL
10 mM	0.2589 mL	1.2943 mL	2.5887 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.70%

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Data Sheet (270 KB) SDS (252 KB)

COA (249 KB)

Handling Instructions (2659 KB)

References

[1]. Hayakawa M, et al. Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110alpha inhibitors. Bioorg Med Chem. 2006 Oct 15;14(20):6847-58. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5887 mL	12.9433 mL	25.8866 mL	64.7165 mL
	5 mM	0.5177 mL	2.5887 mL	5.1773 mL	12.9433 mL
	10 mM	0.2589 mL	1.2943 mL	2.5887 mL	6.4717 mL
	15 mM	0.1726 mL	0.8629 mL	1.7258 mL	4.3144 mL
	20 mM	0.1294 mL	0.6472 mL	1.2943 mL	3.2358 mL
	25 mM	0.1035 mL	0.5177 mL	1.0355 mL	2.5887 mL