PI3Kα-IN-8

Cat. No.: HY-147983: FAQs
Data Sheet Handling Instructions

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PI3Kα-IN-8 (Compound 9g) is a selective PI3Kα inhibitor with an IC₅₀ of 0.012 μM. PI3Kα-IN-8 increases intracellular reactive oxygen species level, decreases mitochondrial membrane potential and induces apoptosis.

For research use only. We do not sell to patients.

PI3Kα-IN-8 Chemical Structure

CAS No. : 2315320-24-0

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

PI3Kα

0.012 μM (IC₅₀)

PI3Kδ

0.11 μM (IC₅₀)

PI3Kγ

0.18 μM (IC₅₀)

PI3Kβ

0.21 μM (IC₅₀)

In Vitro

PI3Kα-IN-8 (Compound 9g) exhibits anticancer activity with IC₅₀ values of 0.18 ± 0.03, 0.43 ± 0.05, 0.71 ± 0.08 and 0.63 ± 0.09 μM against HCT-116, MCF-7, HeLa and HepG2 cells, respectively^[1].
PI3Kα-IN-8 upregulates Bax and cleaved caspase-3/9 levels, and downregulates Bcl-2 level^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

507.42

Formula

C₂₆H₂₇BrN₄O₂

CAS No.

2315320-24-0

SMILES

C[C@@]12C3=CC(Br)=C(N=C(N4)NC5=CC=C(C=C5)C#N)C4=C3CC[C@@]1([H])[C@@](C)(CCC2)C(OC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yang YQ, et al. Synthesis and anticancer evaluation of novel 1H-benzo[d]imidazole derivatives of dehydroabietic acid as PI3Kα inhibitors. Bioorg Chem. 2020 Jul;100:103845. [Content Brief]

PI3Kα-IN-8 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3Kα-IN-82315320-24-0PI3KReactive Oxygen SpeciesApoptosisPhosphoinositide 3-kinaseHCT-116anticancerMCF-7HeLaHepG2Inhibitorinhibitorinhibit

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