2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Pilsicainide

Pilsicainide  (Synonyms: SUN 1165 free base; Pilzicainide)

Cat. No.: HY-133715
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Pilsicainide (SUN 1165 free acid) is a potent sodium channel blocker and potent class Ic antiarrhythmic agent.

For research use only. We do not sell to patients.

Pilsicainide Chemical Structure

Pilsicainide Chemical Structure

CAS No. : 88069-67-4

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Pilsicainide Related Antibodies

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Description

Pilsicainide (SUN 1165 free acid) is a potent sodium channel blocker and potent class Ic antiarrhythmic agent[1][2].

In Vitro

Pilsicainide (SUN 1165 free acid; 10-200 μg/mL) decreases peak amplitude of the net inward current in a dose-dependent manner with an IC50 of 29.2 μg/mL in levo-thyroxine (T4)-treated rat atrial cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pilsicainide Related Antibodies
In Vivo

Pilsicainide (SUN 1165 free acid; 2 mg/kg; i.v.; once) decreases the conduction velocity in T4-treated rat atrium by decreasing the Max dV/dt and net inward current[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley (SD) rats weighing from 200 to 220 g, with levo-thyroxine (T4) treatment[1]
Dosage: 2 mg/kg
Administration: Bolus injection into right external carotid vein within 2 minutes, once
Result: Elongated the QT interval at 15 and 60 minutes after administration.
Shortened P wave and QRS complex durations.
Markedly decreased action potential amplitudes (APA) and Max dV/dt, and significantly lengthened the action potential durations.
Clinical Trial
Molecular Weight

272.39

Formula

C17H24N2O
CAS No.
SMILES

O=C(NC1=C(C)C=CC=C1C)CC23CCCN2CCC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Pilsicainide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pilsicainide88069-67-4SUN 1165 PilzicainideSUN1165SUN-1165Sodium ChannelNa channelsNa+ channelsatrial tachyarrhythmiasantiarrhythmicorally activeInhibitorinhibitorinhibit

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