2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Pilsicainide hydrochloride

Pilsicainide hydrochloride  (Synonyms: SUN-1165; Pilzicainide(hydrochloride))

Cat. No.: HY-101245 Purity: 99.94%
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Pilsicainide hydrochloride (SUN-1165) is an orally active sodium channel blocker and potent class Ic antiarrhythmic agent.

For research use only. We do not sell to patients.

Pilsicainide hydrochloride Chemical Structure

Pilsicainide hydrochloride Chemical Structure

CAS No. : 88069-49-2

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5 mg USD 26 In-stock
10 mg USD 40 In-stock
25 mg USD 80 In-stock
50 mg USD 110 In-stock
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Based on 1 publication(s) in Google Scholar

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Pilsicainide hydrochloride Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Pilsicainide hydrochloride (SUN-1165) is an orally active sodium channel blocker and potent class Ic antiarrhythmic agent[1][2].

In Vitro

Pilsicainide hydrochloride (SUN-1165) (10-200 μg/mL) decreases peak amplitude of the net inward current in a dose-dependent manner with an IC50 of 29.2 ± 22.9 μg/mL in levo-thyroxine (T4)-treated rat atrial cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pilsicainide hydrochloride Related Antibodies
In Vivo

Pilsicainide hydrochloride (SUN-1165) (2 mg/kg; i.v.; once) decreases the conduction velocity in T4-treated rat atrium by decreasing the Max dV/dt and net inward current[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley (SD) rats weighing from 200 to 220 g, with levo-thyroxine (T4) treatment[1]
Dosage: 2 mg/kg
Administration: Bolus injection into right external carotid vein within 2 minutes, once
Result: Result: the QT interval was significantly elongated at 15 and 60 minutes after administration. P wave and QRS complex durations were significantly shortened. Markedly decreased action potential amplitudes (APA) and Max dV/dt, and significantly lengthened the action potential durations.
Clinical Trial
Molecular Weight

308.85

Formula

C17H25ClN2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CC12N(CCC2)CCC1)NC3=C(C)C=CC=C3C.Cl
Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (323.78 mM; Need ultrasonic)

DMSO : 50 mg/mL (161.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2378 mL 16.1891 mL 32.3782 mL
5 mM 0.6476 mL 3.2378 mL 6.4756 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 3.2378 mL 16.1891 mL 32.3782 mL 80.9454 mL
5 mM 0.6476 mL 3.2378 mL 6.4756 mL 16.1891 mL
10 mM 0.3238 mL 1.6189 mL 3.2378 mL 8.0945 mL
15 mM 0.2159 mL 1.0793 mL 2.1585 mL 5.3964 mL
20 mM 0.1619 mL 0.8095 mL 1.6189 mL 4.0473 mL
25 mM 0.1295 mL 0.6476 mL 1.2951 mL 3.2378 mL
30 mM 0.1079 mL 0.5396 mL 1.0793 mL 2.6982 mL
40 mM 0.0809 mL 0.4047 mL 0.8095 mL 2.0236 mL
50 mM 0.0648 mL 0.3238 mL 0.6476 mL 1.6189 mL
60 mM 0.0540 mL 0.2698 mL 0.5396 mL 1.3491 mL
80 mM 0.0405 mL 0.2024 mL 0.4047 mL 1.0118 mL
100 mM 0.0324 mL 0.1619 mL 0.3238 mL 0.8095 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Pilsicainide hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pilsicainide88069-49-2SUN-1165 Pilzicainide(hydrochloride)SUN1165SUN 1165Sodium ChannelNa channelsNa+ channelsatrial tachyarrhythmiasantiarrhythmicorally activeInhibitorinhibitorinhibit

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