2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Pirenperone

Pirenperone  (Synonyms: R 47465)

Cat. No.: HY-B1737 Purity: 98.74%
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Pirenperone (R 47465) is a 5-HT2 serotonin receptor antagonist. Pirenperone exhibits modest anxiolytic activity.

For research use only. We do not sell to patients.

Pirenperone Chemical Structure

Pirenperone Chemical Structure

CAS No. : 75444-65-4

Size Price Stock Quantity
1 mg USD 45 In-stock
5 mg USD 90 In-stock
10 mg USD 145 In-stock
25 mg USD 290 In-stock
50 mg USD 460 In-stock
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Based on 1 publication(s) in Google Scholar

Pirenperone Related Antibodies

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Description

Pirenperone (R 47465) is a 5-HT2 serotonin receptor antagonist. Pirenperone exhibits modest anxiolytic activity[1][2].

Molecular Weight

393.45

Formula

C23H24FN3O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1C(CCN2CCC(C(C3=CC=C(F)C=C3)=O)CC2)=C(C)N=C4N1C=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (63.54 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

0.1 M HCL : 16.67 mg/mL (42.37 mM; ultrasonic and warming and adjust pH to 3 with 0.1 M HCL and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5416 mL 12.7081 mL 25.4162 mL
5 mM 0.5083 mL 2.5416 mL 5.0832 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
0.1 M HCL / DMSO 1 mM 2.5416 mL 12.7081 mL 25.4162 mL 63.5405 mL
5 mM 0.5083 mL 2.5416 mL 5.0832 mL 12.7081 mL
10 mM 0.2542 mL 1.2708 mL 2.5416 mL 6.3540 mL
15 mM 0.1694 mL 0.8472 mL 1.6944 mL 4.2360 mL
20 mM 0.1271 mL 0.6354 mL 1.2708 mL 3.1770 mL
25 mM 0.1017 mL 0.5083 mL 1.0166 mL 2.5416 mL
30 mM 0.0847 mL 0.4236 mL 0.8472 mL 2.1180 mL
40 mM 0.0635 mL 0.3177 mL 0.6354 mL 1.5885 mL
DMSO 50 mM 0.0508 mL 0.2542 mL 0.5083 mL 1.2708 mL
60 mM 0.0424 mL 0.2118 mL 0.4236 mL 1.0590 mL
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Pirenperone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pirenperone75444-65-4R 47465R47465R-474655-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptorserotonin receptoranxiolytic activityInhibitorinhibitorinhibit

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