PKA Regulatory Subunit II Substrate  (Synonyms: RII phosphopeptide)

PKA Regulatory Subunit II Substrate (RII phosphopeptide) is a tool peptide derived from the regulatory subunit Type II (RII) of cyclic AMP-dependent protein kinase (PKA). PKA Regulatory Subunit II Substrate is commonly used to mimic the phosphorylation of protein kinases and as a specific substrate for protein phosphatases to assess the activities of these enzymes^[1].

2192.33

C₉₂H₁₅₁N₂₈O₃₂P

103659-06-9

Asp-Leu-Asp-Val-Pro-Ile-Pro-Gly-Arg-Phe-Asp-Arg-Arg-Val-{pSer}-Val-Ala-Ala-Glu

DLDVPIPGRFDRRV-{pSer}-VAAE

OC(C[C@H](N)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N1[C@@H](CCC1)C(N[C@@H]([C@@H](C)CC)C(N2[C@@H](CCC2)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](COP(O)(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@H](C(O)=O)CCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang Lu, et al. "A novel peptide exerts potent immunosuppression by blocking the two-site interaction of NFAT with calcineurin." Journal of Biological Chemistry 295.9 (2020): 2760-2770.  [Content Brief]